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Nanosensors for cancer detection.
Journal article

Nanosensors for cancer detection.

  • Huber F SNI, Swiss Nano Institute, Institute of Physics, University of Basel, Basel, Switzerland.
  • Lang HP SNI, Swiss Nano Institute, Institute of Physics, University of Basel, Basel, Switzerland.
  • Zhang J SNI, Swiss Nano Institute, Institute of Physics, University of Basel, Basel, Switzerland.
  • Rimoldi D Ludwig Center for Cancer Research of the University of Lausanne, Épalinges VD, Switzerland.
  • Gerber C SNI, Swiss Nano Institute, Institute of Physics, University of Basel, Basel, Switzerland.
  • 2015-02-10
Published in:
  • Swiss medical weekly. - 2015
Biomarkers, Tumor
Biosensing Techniques
Early Detection of Cancer
Humans
Microscopy, Atomic Force
Nanotechnology
English Cancer is a major burden in today's society and one of the leading causes of death in industrialised countries. Various avenues for the detection of cancer exist, most of which rely on standard methods, such as histology, ELISA, and PCR. Here we put the focus on nanomechanical biosensors derived from atomic force microscopy cantilevers. The versatility of this novel technology has been demonstrated in different applications and in some ways surpasses current technologies, such as microarray, quartz crystal microbalance and surface plasmon resonance. The technology enables label free biomarker detection without the necessity of target amplification in a total cellular background, such as BRAF mutation analysis in malignant melanoma. A unique application of the cantilever array format is the analysis of conformational dynamics of membrane proteins associated to surface stress changes. Another development is characterisation of exhaled breath which allows assessment of a patient's condition in a non-invasive manner.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/299007
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