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Genomic patterns and context specific interpretation of DNA methylation.
Journal article

Genomic patterns and context specific interpretation of DNA methylation.

  • Baubec T Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland. Electronic address: tuncay.baubec@fmi.ch.
  • Schübeler D Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland; University of Basel, Faculty of Science, Petersplatz 1, Basel 4003, Switzerland. Electronic address: dirk@fmi.ch.
  • 2014-03-12
Published in:
  • Current opinion in genetics & development. - 2014
Animals
CpG Islands
DNA Methylation
Gene Expression Regulation
Genome
Humans
English Methylation of CpG dinucleotides is a reversible modification of DNA that is highly prevalent throughout mammalian genomes. Recent advances generated genomic DNA methylation maps during cellular differentiation at unprecedented resolution. Combined with functional assays this revealed that dynamics in DNA methylation coincide with changes in regulatory activity and that transcription factors play an important role in shaping methylation patterns. This tightly links DNA methylation with underlying DNA sequence features and suggests that a substantial fraction of methylation changes occur downstream of gene regulation. Here we discuss our current understanding of the context-dependent readout of DNA methylation and criteria that need to be fulfilled for this modification to be instructive for gene regulation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/299043
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