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Influence of age and cognitive performance on resting-state brain networks of older adults in a population-based cohort.
Journal article

Influence of age and cognitive performance on resting-state brain networks of older adults in a population-based cohort.

  • Jockwitz C Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
  • Caspers S Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany. Electronic address: svenja.caspers@hhu.de.
  • Lux S Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
  • Eickhoff SB Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Institute Clinical Neuroscience and Medical Psychology, University of Düsseldorf, Düsseldorf, Germany; Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Jütten K Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
  • Lenzen S Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
  • Moebus S Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
  • Pundt N Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
  • Reid A Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany.
  • Hoffstaedter F Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Institute Clinical Neuroscience and Medical Psychology, University of Düsseldorf, Düsseldorf, Germany; Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Jöckel KH Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
  • Erbel R Heinz Nixdorf Recall Study, Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
  • Cichon S Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany; Division of Medical Genetics, University Hospital Basel, Basel, Switzerland.
  • Nöthen MM Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
  • Shah NJ Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany; Department of Neurology, RWTH Aachen University, Aachen, Germany.
  • Zilles K Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
  • Amunts K Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
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  • 2017-02-14
Published in:
  • Cortex; a journal devoted to the study of the nervous system and behavior. - 2017
Aging
Cognition
Functional connectivity
ICA
Resting state
Age Factors
Aged
Aged, 80 and over
Aging
Attention
Brain
Brain Mapping
Cognition
Executive Function
Female
Functional Laterality
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
Middle Aged
Nerve Net
Neuropsychological Tests
Rest
English Aging leads to global changes in brain structure and cognitive performance, with reorganization of functional brain networks. Importantly, these age-related changes show higher inter-individual variability in older subjects. To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood. The present study therefore had a dedicated focus on late adulthood to characterize the functional connectivity in resting-state networks (RSFC) in relation to age and cognitive performance in 711 older adults (55-85 years) from the 1000BRAINS project. The executive, left and right frontoparietal resting-state (RS) networks showed age-related increases in RSFC. However, older adults did not show changes in RSFC in the default mode network (DMN). Furthermore, lower performance in working memory (WM) was associated with higher RSFC in the left frontoparietal RS network. The results suggest age-related compensatory increases in RSFC which might help to maintain cognitive performance. Nevertheless, the negative correlation between RSFC and WM performance hints at limited cognitive reserve capacity in lower performing older adults. Consequently, the current results provide evidence for a functional reorganization of the brain until late adulthood that might additionally explain parts of the variability of cognitive abilities in older adults.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/299296
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