Journal article

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

  • Nolte IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Munoz ML Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Tragante V Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
  • Amare AT Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Jansen R Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
  • Vaez A Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • von der Heyde B Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
  • Avery CL Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Bis JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
  • Dierckx B Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • van Dongen J Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Gogarten SM Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Goyette P Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
  • Hernesniemi J Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Huikari V Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
  • Hwang SJ Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Jaju D Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat-Al Khoudh 123, Sultanate of Oman.
  • Kerr KF Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Kluttig A Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06097, Germany.
  • Krijthe BP Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Kumar J Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
  • van der Laan SW Laboratory of Experimental Cardiology, Department of Heart and Lung, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
  • Lyytikäinen LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Maihofer AX Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • Minassian A Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • van der Most PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Müller-Nurasyid M Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Nivard M Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Salvi E Department of Health Sciences, University of Milano, Milano 20122, Italy.
  • Stewart JD Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Thayer JF Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, Ohio 43210, USA.
  • Verweij N Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Wong A MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK.
  • Zabaneh D Institute of Psychiatry, Psychology &Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
  • Zafarmand MH Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
  • Abdellaoui A Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Albarwani S Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman.
  • Albert C Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Alonso A Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
  • Ashar F McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Auvinen J Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
  • Axelsson T Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden.
  • Baker DG Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA.
  • de Bakker PIW Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
  • Barcella M Department of Health Sciences, University of Milano, Milano 20122, Italy.
  • Bayoumi R College of Medicine, Mohammed Bin Rashid University, PO Box 505055, Dubai Healthcare City, United Arab Emirates.
  • Bieringa RJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Boomsma D Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Boucher G Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
  • Britton AR Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
  • Christophersen I Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Dietrich A Department of Child- and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Ehret GB Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Ellinor PT Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.
  • Eskola M Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.
  • Felix JF Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Floras JS University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada M5S.
  • Franco OH Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Friberg P Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
  • Gademan MGJ Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
  • Geyer MA Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • Giedraitis V Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 75237, Sweden.
  • Hartman CA Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Hemerich D Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
  • Hofman A Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Hottenga JJ Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Huikuri H Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.
  • Hutri-Kähönen N Department of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.
  • Jouven X INSERM U970, Paris Descartes University, Paris 75006, France.
  • Junttila J Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.
  • Juonala M Department of Medicine, University of Turku, Turku 20520, Finland.
  • Kiviniemi AM Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.
  • Kors JA Department of Medical Informatics, Erasmus Medical Center, Rotterdam 3015 CE, The Netherlands.
  • Kumari M Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
  • Kuznetsova T Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium.
  • Laurie CC Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Lefrandt JD Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Li Y Division of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany.
  • Li Y Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Liao D Division of Epidemiology, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.
  • Limacher MC Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32611, USA.
  • Lin HJ Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
  • Lindgren CM Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK.
  • Lubitz SA Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.
  • Mahajan A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • McKnight B Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
  • Zu Schwabedissen HM Biopharmacy, Department Pharmaceutical Sciences, University of Basel, Basel CH-4056, Switzerland.
  • Milaneschi Y Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
  • Mononen N Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Morris AP Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Nalls MA Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Navis G Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Neijts M Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Nikus K Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.
  • North KE Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • O'Connor DT Department of Medicine, University of California, San Diego, San Diego, California 92093, USA.
  • Ormel J Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Perz S Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Peters A DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany.
  • Psaty BM Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
  • Raitakari OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
  • Risbrough VB Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • Sinner MF Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.
  • Siscovick D The New York Academy of Medicine, New York, New York 10029, USA.
  • Smit JH Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
  • Smith NL Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.
  • Soliman EZ Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
  • Sotoodehnia N Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98101, USA.
  • Staessen JA Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium.
  • Stein PK Heart Rate Variability Lab, Washington University School of Medicine, St Louis, Missouri 63108, USA.
  • Stilp AM Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Stolarz-Skrzypek K First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Cracow 31-008, Poland.
  • Strauch K Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Sundström J Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
  • Swenne CA Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Syvänen AC Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden.
  • Tardif JC Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
  • Taylor KD Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA.
  • Teumer A Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
  • Thornton TA Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Tinker LE Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Uitterlinden AG Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • van Setten J Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
  • Voss A Institute of Innovative Health Technologies-IGHT Jena Ernst-Abbe-Hochschule Jena, Jena 07745, Germany.
  • Waldenberger M Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Wilhelmsen KC Departments of Genetics and Neurology University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Willemsen G Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Wong Q Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Zhang ZM Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
  • Zonderman AB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Cusi D Institute of Biomedical Technologies, CNR-Italian National Research Council, Milan 20090, Italy.
  • Evans MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Greiser HK German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg 69210, Germany.
  • van der Harst P Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Hassan M Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman.
  • Ingelsson E Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
  • Järvelin MR Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
  • Kääb S Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.
  • Kähönen M Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
  • Kivimaki M Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
  • Kooperberg C Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Kuh D MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK.
  • Lehtimäki T Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Lind L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
  • Nievergelt CM Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • O'Donnell CJ Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Oldehinkel AJ Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Penninx B Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
  • Reiner AP Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Riese H Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • van Roon AM Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Rioux JD Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
  • Rotter JI Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA.
  • Sofer T Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Stricker BH Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Tiemeier H Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Vrijkotte TGM Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
  • Asselbergs FW Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
  • Brundel BJJM Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1118, Amsterdam 1081 HV, The Netherlands.
  • Heckbert SR Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
  • Whitsel EA Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • den Hoed M Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
  • Snieder H Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • de Geus EJC Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
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  • 2017-06-15
Published in:
  • Nature communications. - 2017
English Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74
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  • English
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https://sonar.ch/global/documents/299355
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