Journal article

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

  • Wuttke M Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
  • Li Y Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
  • Li M Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
  • Sieber KB Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Feitosa MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • Gorski M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
  • Tin A Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Wang L Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • Chu AY Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Hoppmann A Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
  • Kirsten H Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
  • Giri A Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Chai JF Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Sveinbjornsson G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Tayo BO Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
  • Nutile T Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
  • Fuchsberger C Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • Marten J Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Cocca M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Ghasemi S Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Xu Y Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
  • Horn K Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
  • Noce D Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • van der Most PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Sedaghat S Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Yu Z Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Akiyama M Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
  • Afaq S Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
  • Ahluwalia TS Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Almgren P Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
  • Amin N Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Ärnlöv J Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Bakker SJL Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Bansal N Division of Nephrology, University of Washington, Seattle, WA, USA.
  • Baptista D Cardiology, Geneva University Hospitals, Geneva, Switzerland.
  • Bergmann S Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
  • Biggs ML Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Biino G Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
  • Boehnke M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Boerwinkle E Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
  • Boissel M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
  • Bottinger EP Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Boutin TS Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Brenner H Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Brumat M Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Burkhardt R LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Butterworth AS MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Campana E Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Campbell A Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Campbell H Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Canouil M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
  • Carroll RJ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Catamo E Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Chambers JC Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
  • Chee ML Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Chee ML Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Chen X Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Cheng CY Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Cheng Y Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
  • Christensen K Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.
  • Cifkova R Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.
  • Ciullo M Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
  • Concas MP Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Cook JP Department of Biostatistics, University of Liverpool, Liverpool, UK.
  • Coresh J Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Corre T Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
  • Sala CF San Raffaele Research Institute, Milan, Italy.
  • Cusi D Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy.
  • Danesh J Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Daw EW Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • de Borst MH Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • De Grandi A Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • de Mutsert R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • de Vries APJ Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
  • Degenhardt F Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Delgado G Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Demirkan A Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Di Angelantonio E Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Dittrich K Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
  • Divers J Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Dorajoo R Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
  • Eckardt KU Intensive Care Medicine, Charité, Berlin, Germany.
  • Ehret G Cardiology, Geneva University Hospitals, Geneva, Switzerland.
  • Elliott P Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Endlich K DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Evans MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
  • Felix JF Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Foo VHX Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Franco OH Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Franke A Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Freedman BI Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Freitag-Wolf S Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Friedlander Y School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Froguel P CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
  • Gansevoort RT Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Gao H Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Gasparini P Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Gaziano JM Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
  • Giedraitis V Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
  • Gieger C Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Girotto G Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Giulianini F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Gögele M Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • Gordon SD QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Gudbjartsson DF deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Gudnason V Icelandic Heart Association, Kopavogur, Iceland.
  • Haller T Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Hamet P Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada.
  • Harris TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
  • Hartman CA Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Hayward C Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Hellwege JN Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Heng CK Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Hicks AA Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • Hofer E Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
  • Huang W Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China.
  • Hutri-Kähönen N Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
  • Hwang SJ NHLBI's Framingham Heart Study, Framingham, MA, USA.
  • Ikram MA Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Indridason OS Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
  • Ingelsson E Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Ising M Max Planck Institute of Psychiatry, Munich, Germany.
  • Jaddoe VWV Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Jakobsdottir J The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
  • Jonas JB Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
  • Joshi PK Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Josyula NS Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
  • Jung B Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
  • Kähönen M Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
  • Kamatani Y Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
  • Kammerer CM Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • Kanai M Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
  • Kastarinen M Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
  • Kerr SM Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Khor CC Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Kiess W LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Kleber ME Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Koenig W Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
  • Kooner JS Department of Cardiology, Ealing Hospital, Middlesex, UK.
  • Körner A LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Kovacs P Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
  • Kraja AT Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • Krajcoviechova A Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.
  • Kramer H Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
  • Krämer BK Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Kronenberg F Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kubo M RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
  • Kühnel B Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Kuokkanen M The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
  • Kuusisto J Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
  • La Bianca M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Laakso M Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
  • Lange LA Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
  • Langefeld CD Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Lee JJ Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Lehne B Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
  • Lehtimäki T Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Lieb W Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
  • Lim SC Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Lind L Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Lindgren CM Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Liu J Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
  • Liu J Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
  • Loeffler M Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Loos RJF Max Planck Institute of Psychiatry, Munich, Germany.
  • Lucae S Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA.
  • Lukas MA Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Lyytikäinen LP Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Mägi R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Magnusson PKE Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
  • Mahajan A QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Martin NG Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Martins J Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
  • März W Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • Mascalzoni D Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Matsuda K Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Meisinger C DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
  • Meitinger T Hypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden.
  • Melander O Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Metspalu A deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Mikaelsdottir EK Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
  • Milaneschi Y Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Miliku K Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Mishra PP Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  • Mohlke KL Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.
  • Mononen N Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Montgomery GW Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA.
  • Mook-Kanamori DO Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Mychaleckyj JC Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Nadkarni GN DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Nalls MA Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
  • Nauck M Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Nikus K Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Ning B Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
  • Nolte IM University of Maryland School of Medicine, Baltimore, MD, USA.
  • Noordam R Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
  • O'Connell J Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
  • O'Donoghue ML Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Olafsson I Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
  • Oldehinkel AJ Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Orho-Melander M Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Ouwehand WH Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Padmanabhan S Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Palmer ND Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
  • Palsson R Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
  • Penninx BWJH National Institute for Health and Welfare, Helsinki, Finland.
  • Perls T Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
  • Perola M Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Pirastu M Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
  • Pirastu N Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Pistis G Faculty of Medicine, University of Split, Split, Croatia.
  • Podgornaia AI Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland.
  • Polasek O Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Ponte B LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Porteous DJ Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
  • Poulain T Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Pramstaller PP MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Preuss MH Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  • Prins BP Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
  • Province MA Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  • Rabelink TJ Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
  • Raffield LM Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
  • Raitakari OT Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
  • Reilly DF Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
  • Rettig R Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Rheinberger M Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Rice KM Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Ridker PM Department of Health Sciences, University of Milan, Milano, Italy.
  • Rivadeneira F NHS Blood and Transplant, BRC Oxford Haematology Theme; Nuffield Division of Clinical Laboratory Sciences; University of Oxford, Oxford, UK.
  • Rizzi F Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
  • Roberts DJ Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Robino A Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Rossing P Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
  • Rudan I Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
  • Rueedi R Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Ruggiero D Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
  • Ryan KA Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Saba Y National Institute for Health and Welfare, Helsinki, Finland.
  • Sabanayagam C Department of Health Sciences, University of Milan, Milano, Italy.
  • Salomaa V Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Salvi E Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.
  • Saum KU Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
  • Schmidt H Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schmidt R Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
  • Schöttker B Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Schulz CA Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Schupf N Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Shaffer CM Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Shi Y Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
  • Smith AV Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
  • Smith BH Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  • Soranzo N Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Spracklen CN Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Strauch K Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
  • Stringham HM Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
  • Stumvoll M Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Svensson PO Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Szymczak S Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
  • Tai ES Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Tajuddin SM The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Tan NYQ LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Taylor KD Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
  • Teren A LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Tham YC Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Thiery J Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Thio CHL deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Thomsen H San Raffaele Research Institute, Milan, Italy.
  • Thorleifsson G Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
  • Toniolo D Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada.
  • Tönjes A Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Tremblay J Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Tzoulaki I Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
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  • Köttgen A
  • Pattaro C
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  • 2019-06-02
Published in:
  • Nature genetics. - 2019
English Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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