A catalog of genetic loci associated with kidney function from analyses of a million individuals.
Wuttke MInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Li YInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Li MDivision of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
Sieber KBTarget Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Feitosa MFDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Gorski MDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Tin ADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Wang LDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Chu AYGenetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Hoppmann AInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Kirsten HInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Giri ADivision of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Chai JFSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Tayo BODepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Nutile TInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Fuchsberger CEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Marten JMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Cocca MInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Ghasemi SInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Xu YDivision of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
Horn KInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Noce DEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
van der Most PJDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sedaghat SDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Yu ZDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Akiyama MLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Afaq SDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Ahluwalia TSSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Almgren PDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Amin NDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ärnlöv JDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Bakker SJLDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bansal NDivision of Nephrology, University of Washington, Seattle, WA, USA.
Baptista DCardiology, Geneva University Hospitals, Geneva, Switzerland.
Bergmann SDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Biggs MLCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Biino GInstitute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Boehnke MDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Boerwinkle EHuman Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
Boissel MCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Bottinger EPCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Boutin TSMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Brenner HDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brumat MDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Burkhardt RLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Butterworth ASMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Campana EDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Campbell ACenter for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Campbell HCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Canouil MCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Carroll RJDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Catamo EInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Chambers JCDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Chee MLSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Chee MLSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Chen XDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Cheng CYSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Cheng YInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Christensen KUnit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.
Cifkova RCenter for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.
Ciullo MInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Concas MPInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Cook JPDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Coresh JDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Corre TDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Sala CFSan Raffaele Research Institute, Milan, Italy.
Cusi DInstitute of Biomedical Technologies, National Research Council of Italy, Milan, Italy.
Danesh JDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Daw EWDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
de Borst MHDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
De Grandi AEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
de Mutsert RDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
de Vries APJSection of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Degenhardt FInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Delgado GDepartment of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Demirkan ADepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Di Angelantonio EDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dittrich KDepartment of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Divers JPublic Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Dorajoo RGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Eckardt KUIntensive Care Medicine, Charité, Berlin, Germany.
Ehret GCardiology, Geneva University Hospitals, Geneva, Switzerland.
Elliott PDepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Endlich KDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Evans MKLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Felix JFDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Foo VHXSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Franco OHDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Franke AInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Freedman BISection on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Freitag-Wolf SInstitute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Friedlander YSchool of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Froguel PCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Gansevoort RTDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gao HDepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Gasparini PInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Gaziano JMMassachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
Giedraitis VMolecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Gieger CResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Girotto GInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Giulianini FDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Gögele MEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Gordon SDQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Haller TEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hamet PMontreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada.
Harris TBLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
Hartman CAInterdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Hayward CMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hellwege JNVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Heng CKDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Hicks AAEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Hofer EClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Huang WDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China.
Hutri-Kähönen NDepartment of Pediatrics, Tampere University Hospital, Tampere, Finland.
Hwang SJNHLBI's Framingham Heart Study, Framingham, MA, USA.
Ikram MADepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Indridason OSDivision of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Ingelsson EDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Ising MMax Planck Institute of Psychiatry, Munich, Germany.
Jaddoe VWVDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jakobsdottir JThe Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
Jonas JBDepartment of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Joshi PKCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Josyula NSGeisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
Jung BDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Kähönen MDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Kamatani YLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Kammerer CMDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kanai MLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Kastarinen MDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Kerr SMMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Khor CCSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Kiess WLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Kleber MEDepartment of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Koenig WDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Kooner JSDepartment of Cardiology, Ealing Hospital, Middlesex, UK.
Körner ALIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Kovacs PIntegrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Kraja ATDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Krajcoviechova ACenter for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.
Kramer HDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Krämer BKDepartment of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kronenberg FDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Kubo MRIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
Kühnel BResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Kuokkanen MThe Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Kuusisto JDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
La Bianca MInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Laakso MDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Lange LADivision of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
Langefeld CDPublic Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lee JJSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Lehne BDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Lehtimäki TDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Lieb WInstitute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
Lim SCCardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Lind LNuffield Department of Medicine, University of Oxford, Oxford, UK.
Lindgren CMDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Liu JGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Liu JInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Loeffler MCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Loos RJFMax Planck Institute of Psychiatry, Munich, Germany.
Lucae STarget Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA.
Lukas MADepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Lyytikäinen LPEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mägi RDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Magnusson PKEWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
Mahajan AQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Martin NGDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Martins JSynlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
März WEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Mascalzoni DLaboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Matsuda KIndependent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Meisinger CDZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Meitinger THypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden.
Melander OEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mikaelsdottir EKDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Milaneschi YDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Miliku KDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Mishra PPDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Mohlke KLInstitute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.
Mononen NDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Montgomery GWCenter for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA.
Mook-Kanamori DOCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mychaleckyj JCLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Nadkarni GNDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Nalls MADepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Nauck MDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Nikus KDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ning BSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Nolte IMUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Noordam RCardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
O'Connell JDepartment of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
O'Donoghue MLInterdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Olafsson IDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Oldehinkel AJDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Orho-Melander MInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Ouwehand WHBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Padmanabhan SFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Palmer NDDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Palsson RDepartment of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Penninx BWJHNational Institute for Health and Welfare, Helsinki, Finland.
Perls TInstitute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
Perola MCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Pirastu MDepartment of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Pirastu NGenetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Pistis GFaculty of Medicine, University of Split, Split, Croatia.
Podgornaia AIService de Néphrologie, Geneva University Hospitals, Geneva, Switzerland.
Polasek OCenter for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Ponte BLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Porteous DJEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Poulain TCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pramstaller PPMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Preuss MHDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Prins BPSection of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Province MADepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Rabelink TJDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Raffield LMGenetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Raitakari OTInstitute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
Reilly DFDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Rettig RDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Rheinberger MDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rice KMDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ridker PMDepartment of Health Sciences, University of Milan, Milano, Italy.
Rivadeneira FNHS Blood and Transplant, BRC Oxford Haematology Theme; Nuffield Division of Clinical Laboratory Sciences; University of Oxford, Oxford, UK.
Rizzi FInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Roberts DJSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Robino ACenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Rossing PDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Rudan IInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Rueedi RDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Ruggiero DMolecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Ryan KASingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Saba YNational Institute for Health and Welfare, Helsinki, Finland.
Sabanayagam CDepartment of Health Sciences, University of Milan, Milano, Italy.
Salomaa VDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Salvi EInstitute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.
Saum KUClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Schmidt HDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Schmidt RDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Schöttker BDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Schulz CADepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Schupf NSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Shaffer CMFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Shi YDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Smith AVHuman Genetics, Wellcome Sanger Institute, Hinxton, UK.
Smith BHDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Soranzo NInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Spracklen CNDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Strauch KDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Stringham HMDepartment of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Stumvoll MInstitute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Svensson POSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Szymczak SLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Tai ESSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Tajuddin SMThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tan NYQLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Taylor KDSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Teren ALIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Tham YCDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Thiery JDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomsen HSan Raffaele Research Institute, Milan, Italy.
Thorleifsson GDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Toniolo DMontreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada.
Tönjes ADepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Tremblay JDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Tzoulaki IInstitute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
Uitterlinden AGSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Vaccargiu SDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
van Dam RMDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
van der Harst PDepartment of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
van Duijn CMDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Velez Edward DRDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Verweij NDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Vogelezang SInternal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Völker UInternal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Vollenweider PResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Waeber GCardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Waldenberger MBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Wallentin LGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Wang YXTarget Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Wang CBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Waterworth DMGreen Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand.
Bin Wei WQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
White HCenter for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Whitfield JBMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Wild SHDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Wilson JFDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Wojczynski MKSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Wong CBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Wong TYDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Xu LSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Yang QTarget Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Yasuda MDepartment of Cardiology, Ealing Hospital, Middlesex, UK.
Yerges-Armstrong LMLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Zhang WThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Zonderman ABInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Rotter JICardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA.
Bochud MMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Psaty BMDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Vitart VDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Wilson JGDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Dehghan ADivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Parsa AKidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA.
Chasman DIDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Ho KInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Morris APKidney Research Institute, University of Washington, Seattle, WA, USA.
Devuyst OGeisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
Akilesh SSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Pendergrass SADepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Sim XLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan.
Böger CADepartment of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Okada YDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Snieder HDepartment of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Stefansson KDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Hung AMInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Heid IMInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Scholz MInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.
Teumer AEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu.
English
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.