DO-HEALTH: Vitamin D3 - Omega3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors.
Journal article

DO-HEALTH: Vitamin D3 - Omega3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors.

  • Bischoff-Ferrari HA Center on Aging and Mobility, University Hospital Zurich, Waid City Hospital and University of Zurich, Zurich, Switzerland; Department of Geriatric Medicine and Aging Research, University Hospital Zurich and University of Zurich, Zurich, Switzerland. Electronic address: Heike.Bischoff@usz.ch.
  • Molino CGRC Center on Aging and Mobility, University Hospital Zurich, Waid City Hospital and University of Zurich, Zurich, Switzerland.
  • Rival S Center on Aging and Mobility, University Hospital Zurich, Waid City Hospital and University of Zurich, Zurich, Switzerland.
  • Vellas B Gérontopôle de Toulouse, Institut du Vieillissement, Center Hospitalo-Universitaire de Toulouse, Toulouse, France; UMR INSERM 1027, University of Toulouse III, Toulouse, France.
  • Rizzoli R Division of Bone Diseases, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland.
  • Kressig RW University Department of Geriatric Medicine FELIX PLATTER, University of Basel, Basel, Switzerland.
  • Kanis JA Centre for Metabolic Bone Diseases, University of Sheffield Medical School, United Kingdom; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
  • Manson JE Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Dawson-Hughes B Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
  • Orav EJ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • da Silva JAP Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
  • Blauth M Department for Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria.
  • Felsenberg D Center for Muscle and Bone Research, Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, , Germany.
  • Ferrari SM Ferrari Data Solutions, Feldmeilen, Switzerland.
  • Theiler R Center on Aging and Mobility, University Hospital Zurich, Waid City Hospital and University of Zurich, Zurich, Switzerland; Department of Geriatric Medicine and Aging Research, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
  • Egli A Center on Aging and Mobility, University Hospital Zurich, Waid City Hospital and University of Zurich, Zurich, Switzerland; Department of Geriatric Medicine and Aging Research, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
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  • 2020-08-29
Published in:
  • Contemporary clinical trials. - 2020
English DO-HEALTH is a multi-center clinical trial among 2157 community-dwelling European men and women age 70 and older. The 2x2x2 randomized-control factorial design trial tested the individual and additive benefit, as well as the cost-effectiveness, of 3 interventions: vitamin D 2000 IU/day, omega-3 fatty acids 1000 mg/day (EPA + DHA, ratio 1:2), and a 30-minute 3 times/week home exercise (strength versus flexibility). Each treatment tested has shown considerable prior promise from mechanistic studies, small clinical trials, or large cohort studies, in the prevention of common age-related chronic diseases, but definitive data are missing. DO-HEALTH will test these interventions in relation to 6 primary endpoints (systolic and diastolic blood pressure, non-vertebral fractures, Short Physical Performance Battery score, the Montreal Cognitive Assessment, and risk of infections), plus several secondary endpoints explored in ancillary studies (i.e. rate of any falls and injurious falls, joint pain, oral health, quality of life, and incident frailty). As the 3 interventions have distinct mechanisms of action for each of the 6 primary endpoints, a maximum benefit is expected for their additive benefit as a "multi-modal" intervention. The trial duration is 3 years with in-person contacts with all participants at 4 clinical visits and by quarterly phone calls. Baseline and follow-up blood samples were collected in all participants to measure changes in 25-hydroxyvitamin D and poly-unsaturated fatty acid concentrations. Our objective was to test interventions that are expected to promote healthy aging and longer life expectancy and that can be easily and safely implemented by older community-dwelling adults.
Language
  • English
Open access status
hybrid
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Persistent URL
https://sonar.ch/global/documents/30432
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