Rapid polymyxin NP test for the detection of polymyxin resistance mediated by the MCR-1/MCR-2 genes

Poirel, Laurent; Larpin, Yu; Dobias, Jan; Stephan, Roger; Decousser, Jean-Winoc; Madec, Jean-Yves; Nordmann, Patrice

doi:10.1016/j.diagmicrobio.2017.09.012

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Journal article

Rapid polymyxin NP test for the detection of polymyxin resistance mediated by the MCR-1/MCR-2 genes

Université de Fribourg

Poirel, Laurent Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland
Larpin, Yu Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Switzerland
Dobias, Jan Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, University of Fribourg, Switzerland
Stephan, Roger Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Switzerland
Decousser, Jean-Winoc Department of Virology, Bacteriology - Infection Control, Parasitology - Mycology, Assistance Publique - Hôpitaux de Paris, Créteil, France - IAME, UMR 1137, INSERM, Paris, France
Madec, Jean-Yves Agence Nationale de Sécurité Sanitaire (Anses), Unité Antibiorésistance et Virulence Bactériennes, Lyon, France
Nordmann, Patrice Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland - Institute for Microbiology, University of Lausanne, Switzerland

01.01.2018

Published in:

Diagnostic Microbiology and Infectious Disease. - 2018, vol. 90, no. 1, p. 7–10

English The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR- 1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans. Sensitivity and specificity were found to be 100%.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language