Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae).

Nwodo NJ; Okoye FB; Lai D; Debbab A; Brun R; Proksch P

doi:10.3390/molecules19055470

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Journal article

Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae).

Nwodo NJ Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria. nwodong@hotmail.com.
Okoye FB Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria. basdenc@yahoo.com.
Lai D Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. Laidaowan123@gmail.com.
Debbab A Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. abdessamad.debbab@uni-dusseldorf.de.
Brun R Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Insitute, CH-4002 Basel, Switzerland. reto.brun@unibas.ch.
Proksch P Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany. Proksch@uni-dusseldorf.de.

2014-04-30

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Molecules (Basel, Switzerland). - 2014

Trypanosoma brucei rhodesiense

English Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of the crude extract. In this study, two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extract of Zapoteca portoricensis and their chemical structures deduced by one dimensional and two dimensional NMR and mass spectrometry. These compounds were isolated for the first time from this plant, and no report has been found on their previous isolation from the genus Zapoteca. Evaluation of their trypanocidal activity showed that compound 1 exhibited potent activity against Trypanosoma brucei rhodesiense with an IC50 value of 3.63 μM and selectivity index of 25.3.

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