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Patent ductus arteriosus generates neonatal hemolytic jaundice with thrombocytopenia in Upshaw-Schulman syndrome.

  • Fujimura Y Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan.
  • Lämmle B Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Tanabe S Department of Pediatrics, Nihonkai General Hospital, Sakata, Japan.
  • Sakai K Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan.
  • Kimura T Department of Pediatrics, Nihonkai General Hospital, Sakata, Japan.
  • Kokame K Department of Molecular Pathogenesis and.
  • Miyata T Department of Molecular Pathogenesis and.
  • Takahashi Y Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan.
  • Taniguchi S Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Kashihara, Japan.
  • Matsumoto M Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan.
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  • 2019-11-08
Published in:
  • Blood advances. - 2019
ADAMTS13 Protein
Bilirubin
Biomarkers
DNA Mutational Analysis
Ductus Arteriosus, Patent
Female
Humans
Infant, Newborn
Japan
Jaundice
Male
Mutation
Purpura, Thrombotic Thrombocytopenic
English Key Points
One third of patients with USS have a neonatal episode of severe hemolytic jaundice with thrombocytopenia induced by an unknown trigger. A USS patient with persisting PDA and recurrent neonatal hemolysis/thrombocytopenia suggests blood flow through the PDA as trigger.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/314
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