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Myeloblastin/proteinase 3 belongs to the set of negatively regulated primary response genes expressed during in vitro myeloid differentiation.
Journal article

Myeloblastin/proteinase 3 belongs to the set of negatively regulated primary response genes expressed during in vitro myeloid differentiation.

  • 1994-04-29
Published in:
  • Biochemical and biophysical research communications. - 1994
Base Sequence
Cell Differentiation
Cell Line
DNA, Complementary
Gene Expression Regulation
Genetic Markers
Granulocytes
Hematopoiesis
Humans
Molecular Sequence Data
Monocytes
Myeloblastin
Peroxidase
RNA, Messenger
Serine Endopeptidases
Tetradecanoylphorbol Acetate
Transcription, Genetic
English Regulation of myeloblastin expression was studied during myeloid differentiation of HL60 cells and compared with that of myeloperoxidase. Induction towards the monocytic pathway of differentiation caused a rapid, marked and parallel down-regulation of both transcripts which were insensitive to cycloheximide. Thus, myeloblastin is directly regulated and, similarly to myeloperoxidase, belongs to the set of primary response genes. Nuclear run-on experiments and RNA half-life determinations revealed that myeloblastin regulation was at both the transcriptional and posttranscriptional levels.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/31856
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