Back
The 3' 5' exonucleases.
Journal article

The 3' 5' exonucleases.

  • Shevelev IV Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
  • Hübscher U
  • 2002-05-04
Published in:
  • Nature reviews. Molecular cell biology. - 2002
Amino Acid Sequence
Animals
DNA Helicases
DNA Polymerase III
DNA Repair
DNA Replication
Exodeoxyribonuclease V
Exodeoxyribonucleases
Humans
Molecular Sequence Data
Phosphoproteins
Protein Structure, Tertiary
RecQ Helicases
Recombination, Genetic
Sequence Alignment
Werner Syndrome Helicase
English Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3' 5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/32139
Statistics
Document views: 21 File downloads: