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Journal article

Signalling in viral entry.

  • Greber UF University of Zürich, Institute of Zoology, Switzerland. ufgreber@zool.unizh.ch
  • 2002-05-23
Published in:
  • Cellular and molecular life sciences : CMLS. - 2002
Adenoviridae
Animals
Cell Survival
Endocytosis
Humans
MAP Kinase Signaling System
Mice
Parvovirus
Proto-Oncogene Proteins p21(ras)
Receptors, Virus
Signal Transduction
Virion
Virus Diseases
Viruses
English Viral infections are serious battles between pathogens and hosts. They can result in cell death, elimination of the virus or latent infection keeping both cells and pathogens alive. The outcome of an infection is often determined by cell signalling. Viruses deliver genomes and proteins with signalling potential into target cells and thereby alter the metabolism of the host. Virus interactions with cell surface receptors can elicit two types of signals, conformational changes of viral particles, and intracellular signals triggering specific cellular reactions. Responses by cells include stimulation of innate and adaptive immunity, growth, proliferation, survival and apoptosis. In addition, virus-activated cell signalling boosts viral entry and gene delivery, as recently shon for adenoviruses and adeno-associated viruses. This review illustrates that multiple activation of host cells during viral entry profoundly impacts the elaborate relationship between hosts and viral pathogens.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/32141
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