Potential vascular actions of 2-methoxyestradiol.

Dubey RK; Jackson EK

doi:10.1016/j.tem.2009.04.007

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Journal article

Potential vascular actions of 2-methoxyestradiol.

Dubey RK Clinic for Reproductive Endocrinology, Department of Obstetrics and Gynecology, Zurich Center for Integrative Human Physiology, University Hospital Zurich, Frauenklinikstrasse, Zurich, Switzerland. Raghvendra.Dubey@usz.ch
Jackson EK

2009-09-08

Published in:

Trends in endocrinology and metabolism: TEM. - 2009

Neovascularization, Pathologic

English 2-Methoxyestradiol (2-ME) is a biologically active metabolite of 17beta-estradiol that appears to inhibit key processes associated with cell replication in vitro. The molecule has been suggested to have potent growth-inhibitory effects on proliferating cells, including smooth muscle cells and endothelial cells, and may be antiangiogenic. Because of these potential roles for 2-ME, its lack of cytotoxicity and low estrogenic activity, we hypothesize that 2-ME could be a valuable therapeutic molecule for prevention and treatment of cardiovascular diseases. Whether 2-ME is as effective in vivo as it is in vitro at modulating vascular processes remains controversial. Here we discuss recent developments regarding mechanisms by which 2-ME might regulate vascular activity and angiogenesis and speculate on the therapeutic implications of these developments.

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