Targeting Beclin 1 for viral subversion of macroautophagy.

Gannagé M; Rämer PC; Münz C

doi:10.4161/auto.6.1.10624

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Journal article

Targeting Beclin 1 for viral subversion of macroautophagy.

Gannagé M Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zürich, Zürich, Switzerland.
Rämer PC
Münz C

2009-12-17

Published in:

Autophagy. - 2010

English We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.

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