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Journal article

Targeting Beclin 1 for viral subversion of macroautophagy.

  • Gannagé M Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zürich, Zürich, Switzerland.
  • Rämer PC
  • Münz C
  • 2009-12-17
Published in:
  • Autophagy. - 2010
Animals
Apoptosis Regulatory Proteins
Autophagy
Beclin-1
Gene Targeting
HIV-1
Humans
Immunity, Innate
Influenza A virus
Membrane Proteins
Models, Biological
Virus Diseases
Viruses
English We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/32457
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