Bone grafts: which is the ideal biomaterial?
- Haugen HJ Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
- Lyngstadaas SP Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
- Rossi F Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Milano, Italy.
- Perale G Industrie Biomediche Insubri SA, Mezzovico-Vira, Switzerland.
- 2019-01-10
Published in:
- Journal of clinical periodontology. - 2019
Bone replacement grafts
bone graft
bone graft substitute
deal biomaterial
Animals
Biocompatible Materials
Bone Substitutes
Bone Transplantation
Cattle
Europe
Heterografts
English
Bovine xenograft materials, followed by synthetic biomaterials, which unfortunately still lack documented predictability and clinical performance, dominate the market for the cranio-maxillofacial area. In Europe, new stringent regulations are expected to further limit the allograft market in the future.
AIM
Within this narrative review, we discuss possible future biomaterials for bone replacement.
SCIENTIFIC RATIONALE FOR STUDY
Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Laboratory studies tend to focus on advanced production methods and novel biomaterial features, which can be costly to produce.
PRACTICAL IMPLICATIONS
In this review, we ask why such a limited number of BGs are clinically available when compared to extensive laboratory studies. We also discuss what features are needed for an ideal BG.
RESULTS
We have identified the key properties of current bone substitutes and have provided important information to guide clinical decision-making and generate new perspectives on bone substitutes. Our results indicated that different mechanical and biological properties are needed despite each having a broad spectrum of variations.
CONCLUSIONS
We foresee bone replacement composite materials with higher levels of bioactivity, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.
AIM
Within this narrative review, we discuss possible future biomaterials for bone replacement.
SCIENTIFIC RATIONALE FOR STUDY
Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Laboratory studies tend to focus on advanced production methods and novel biomaterial features, which can be costly to produce.
PRACTICAL IMPLICATIONS
In this review, we ask why such a limited number of BGs are clinically available when compared to extensive laboratory studies. We also discuss what features are needed for an ideal BG.
RESULTS
We have identified the key properties of current bone substitutes and have provided important information to guide clinical decision-making and generate new perspectives on bone substitutes. Our results indicated that different mechanical and biological properties are needed despite each having a broad spectrum of variations.
CONCLUSIONS
We foresee bone replacement composite materials with higher levels of bioactivity, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1111/jcpe.13058
- PMID 30623986
- Persistent URL
- https://sonar.ch/global/documents/32970
Statistics
Document views: 42
File downloads:
- fulltext.pdf: 0