Transendothelial transport of lipoproteins.
- Jang E Keenan Centre for Biomedical Research, St. Michael's Hospital, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
- Robert J Institute of Clinical Chemistry, University of Zurich and University Hospital of Zurich, Switzerland.
- Rohrer L Institute of Clinical Chemistry, University of Zurich and University Hospital of Zurich, Switzerland.
- von Eckardstein A Institute of Clinical Chemistry, University of Zurich and University Hospital of Zurich, Switzerland. Electronic address: arnold.voneckardstein@usz.ch.
- Lee WL Keenan Centre for Biomedical Research, St. Michael's Hospital, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada; Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Canada; Department of Biochemistry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address: warren.lee@unityhealth.to.
- 2020-10-09
Published in:
- Atherosclerosis. - 2020
English
The accumulation of low-density lipoproteins (LDL) in the arterial wall plays a pivotal role in the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol from the intima by cholesterol efflux to high density lipoproteins (HDL) and subsequent reverse cholesterol transport shall confer protection against atherosclerosis. To reach the subendothelial space, both LDL and HDL must cross the intact endothelium. Traditionally, this transit is explained by passive filtration. This dogma has been challenged by the identification of several rate-limiting factors namely scavenger receptor SR-BI, activin like kinase 1, and caveolin-1 for LDL as well as SR-BI, ATP binding cassette transporter G1, and endothelial lipase for HDL. In addition, estradiol, vascular endothelial growth factor, interleukins 6 and 17, purinergic signals, and sphingosine-1-phosphate were found to regulate transendothelial transport of either LDL or HDL. Thorough understanding of transendothelial lipoprotein transport is expected to elucidate new therapeutic targets for the treatment or prevention of atherosclerotic cardiovascular disease and the development of strategies for the local delivery of drugs or diagnostic tracers into diseased tissues including atherosclerotic lesions.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.atherosclerosis.2020.09.020
- PMID 33032832
- Persistent URL
- https://sonar.ch/global/documents/33638
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