Journal article

Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort.

  • Elicin O Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Broglie MA Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Fankhauser N CTU Bern, and Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
  • Stoeckli SJ Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Pasche P Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Lausanne, Lausanne, Switzerland.
  • Reinhard A Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Lausanne, Lausanne, Switzerland.
  • Bongiovanni M Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, Lausanne, Switzerland.
  • Huber GF Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Morand GB Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Soltermann A Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland.
  • Arnold A Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
  • Dettmer MS Institute of Pathology, University of Bern, Bern, Switzerland.
  • Arnoux A Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Aarau, Aarau, Switzerland.
  • Stauffer E Institute of Pathology, Promed SA, Fribourg, Switzerland.
  • Espeli V Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
  • Martucci F Department of Radiooncology, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
  • Aebersold DM Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Giger R Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
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  • 2018-12-30
Published in:
  • Head & neck. - 2019
English BACKGROUND
Between the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University.


METHODS
With C-statistics, the above-mentioned five staging algorithms were compared for overall and relapse-free survival endpoints in a multi-institutional cohort of OPSCC cases (n = 338) treated with primary surgery.


RESULTS
Pathological UICC 8th ed yielded the highest C-indexes in the entire cohort and in the HPV- subset, whereas MDACC was superior for HPV+ OPSCC. RTOG was the simplest and holistic algorithm with a noninferior discriminatory power.


CONCLUSION
UICC 8th ed, MDACC, and RTOG offer moderate and comparable efficacy for staging in this OPSCC patient cohort undergoing surgical treatment. Notable discrepancy between clinical and pathological UICC 8th ed algorithms poses potential concerns in diagnosis, treatment, research, and data management.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/33747
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