Back
Effect of Single-Agent Rituximab Given at the Standard Schedule or As Prolonged Treatment in Patients With Mantle Cell Lymphoma: A Study of the Swiss Group for Clinical Cancer Research (SAKK)
Journal article

Effect of Single-Agent Rituximab Given at the Standard Schedule or As Prolonged Treatment in Patients With Mantle Cell Lymphoma: A Study of the Swiss Group for Clinical Cancer Research (SAKK)

  • Ghielmini, Michele From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Schmitz, Shu-Fang Hsu From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Cogliatti, Sergio From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Bertoni, Francesco From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Waltzer, Ursula From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Fey, Martin F. From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Betticher, Daniel C. From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Schefer, Hubert From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Pichert, Gabriella From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Stahel, Rolf From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Ketterer, Nicolas From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Bargetzi, Mario From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
  • Cerny, Thomas From the Oncology Institute of Southern Switzerland, Bellinzona; Swiss Institute of Applied Cancer Research Coordinating Centre, Bern; Institute of Medical Oncology, Inselspital, University of Bern; Swiss Reference Centre for Lymphoma Pathology; Kantonsspital, Aarau; Kantonsspital St Gallen, St Gallen; Kantonsspital Luzern, Luzern; Universitätsspital Zürich, CHUV, Lausanne, Switzerland
Show more…
Published in:
  • Journal of Clinical Oncology. - American Society of Clinical Oncology (ASCO). - 2005, vol. 23, no. 4, p. 705-711
Cancer Research
Oncology
English PurposeTo evaluate the effect of single-agent rituximab given at the standard or a prolonged schedule in patients with newly diagnosed, or refractory or relapsed mantle cell lymphoma (MCL).Patients and MethodsAfter induction treatment with the standard schedule (375 mg/m2weekly × 4), patients who were responding or who had stable disease at week 12 from the start of treatment were randomly assigned to no further treatment (arm A) or prolonged rituximab administration (375 mg/m2) every 8 weeks for four times (arm B).ResultsThe trial enrolled 104 patients. After induction, clinical response was 27% with 2% complete responses. Among patients with detectable t(11;14)-positive cells in blood and bone marrow at baseline, four of 20, and one of 14, respectively, became polymerase chain-reaction–negative after induction. Anemia was the only adverse predictor of response in the multivariate analysis. After a median follow-up of 29 months, response rate and duration of response were not significantly different between the two schedules in 61 randomly assigned patients. Median event-free survival (EFS) was 6 months in arm A versus 12 months in arm B; the difference was not significant (P = .1). Prolonged treatment seemed to improve EFS in the subgroup of pretreated patients (5 months in arm A v 11 months in arm B; P = .04). Thirteen percent of patients in arm A and 9% in arm B presented with grade 3 to 4 hematologic toxicity.ConclusionSingle-agent rituximab is active in MCL, but the addition of four single doses at 8-week intervals does not seem to significantly improve response rate, duration of response, or EFS after treatment with the standard schedule.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/339
Statistics
Document views: 37 File downloads: