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Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism.
Journal article

Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism.

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  • 2008-10-16
Published in:
  • Clinical and experimental hypertension (New York, N.Y. : 1993). - 2008
Angiotensin II
Angiotensin II Type 1 Receptor Blockers
Angiotensin-Converting Enzyme Inhibitors
Biomechanical Phenomena
Cells, Cultured
Endothelial Cells
Hemorheology
Humans
Losartan
Models, Biological
Nitric Oxide
Nitric Oxide Synthase Type III
Oxidative Stress
Pulsatile Flow
Renin-Angiotensin System
Stress, Mechanical
Superoxides
Tetrahydroisoquinolines
English Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2(*-) balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2(*-) balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT(1)) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2(*-) production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2(*-). These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT(1) receptor antagonism.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/346
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