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The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies.
Journal article

The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies.

  • Kutluturk I Department of Ophthalmology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
  • Agarwal A Advanced Eye Center, PGIMER, Chandigarh, India.
  • Shulman S Division of Ophthalmology, Tel-Aviv Medical center, Tel-Aviv, Israel.
  • Vitale A Moran Eye Center, University of Utah Health, Salt Lake City, Utah, USA.
  • Parodi MB Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Conrady CD Moran Eye Center, University of Utah Health, Salt Lake City, Utah, USA.
  • Hurtikova K Department of Ophthalmology, Pallas Clinic Olten, Switzerland.
  • Cunha Souza E Department of Ophthalmology, Universidade Federal of Sao Paulo, Sao Paulo, Brazil.
  • Rodriguez EC Department of Ophthalmology, Universidade Federal of Sao Paulo, Sao Paulo, Brazil.
  • Chhablani J Smt.Kanuri Santhamma Retina Vitreous Centre, L.V.Prasad Eye Institute, Hyderabad, India.
  • Tappeiner C Department of Ophthalmology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
  • Gerding H Department of Ophthalmology, Pallas Clinic Olten, Switzerland.
  • Zinkernagel MS Department of Ophthalmology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
  • Tucker W Moorfields Eye Hospital NHS Foundation Trust, London, UK.
  • Munk MR Department of Ophthalmology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
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  • 2020-02-21
Published in:
  • Ocular immunology and inflammation. - 2020
Choroiditis
choroidopathy
inflammation
placoid
relentless
English Purpose: Placoid-pigment-epitheliopathies like Acute-Posterior-Multifocal-Placoid-Pigment Epitheliopathy (APMPPE) and Relentless-Placoid-Choroidopathy (RPC) usually show bilateral involvement. This retrospective case series describes the clinical features with unilateral disease onset.Methods: 21 patients from 9 tertiary referring institutions were collected and evaluated.Results: Seventeen patients were included: 11 (65%) had unilateral placoid-pigment-epitheliopathy consistent with APMPPE, 6 (35%) with RPC (mean age: 28.82 ± 9.1 years). Mean follow-up time was 45 ± 48 months. Forty-one percent fellow-eyes had initial inflammatory signs including vitreous-cells, vascular-sheathing, and ONH swelling. Thirty-five percent developed chorioretinal lesions during follow-up after 19.5 ± 16.9 months. Initial inflammation in fellow-eye was not associated with fellow-eye involvement (p = .5). However, subfoveal choroidal-thickness (SCT) at baseline was significantly thicker in fellow-eyes who developed chorioretinal lesion compared to fellow-eyes who did not (400 ± 70 µm versus 283 ± 127 µm,p = .047).Conclusion: Unaffected fellow-eyes may have inflammatory signs at initial disease-onset and may develop lesions over time. They should be carefully monitored, particularly if they present with an increased SCT.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/352
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