Journal article
Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.
- Popowycz F Section de Chimie de l'Université de Lausanne, BCH, CH-1015 Lausanne-Dorigny, Switzerland.
- Gerber-Lemaire S
- Demange R
- Rodriguez-García E
- Asenjo AT
- Robina I
- Vogel P
- 2001-09-11
Published in:
- Bioorganic & medicinal chemistry letters. - 2001
Animals
Cattle
Drug Design
Drug Evaluation, Preclinical
Enzyme Inhibitors
Inhibitory Concentration 50
Mannosidases
Structure-Activity Relationship
alpha-Mannosidase
English
A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K(i)=7.4 microM) and selective inhibition of alpha-mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0960-894x(01)00477-2
- PMID 11549453
- Persistent URL
- https://sonar.ch/global/documents/35234
Statistics
Document views: 27
File downloads: