The IclR-family regulator BapR controls biofilm formation in B. cenocepacia H111.
- Aguilar C Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
- Schmid N Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
- Lardi M Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
- Pessi G Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
- Eberl L Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.
- 2014-03-25
Published in:
- PloS one. - 2014
Bacterial Proteins
Biofilms
Burkholderia cenocepacia
Extracellular Space
Gene Expression Regulation, Bacterial
Mutation
Peptide Hydrolases
Quorum Sensing
English
In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR influences the expression of extracellular proteases, swimming motility and has a profound impact in the incidence of persister cells, making this regulator an interesting target for persister cells and biofilm eradication.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1371/journal.pone.0092920
- PMID 24658785
- Persistent URL
- https://sonar.ch/global/documents/35776
Statistics
Document views: 28
File downloads:
- Full-text: 0