Mechanotransduction in striated muscle via focal adhesion kinase
- Durieux, A.C. Institute of Anatomy, University of Berne, Berne, Switzerland
- Desplanches, D. Laboratory of Integrative, Cellular and Molecular Physiology, University of Lyon 1, CNRS, 6922 Villeurbanne, France
- Freyssenet, D. Laboratory of Physiology and Physiopathology of Exercise and Handicap, University of Saint Etienne, Saint Etienne, France
- Flück, M. Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Stoke-on-Trent ST7 2HL, U.K.
- 2007-10-25
Published in:
- Biochemical Society Transactions. - Portland Press Ltd.. - 2007, vol. 35, no. 5, p. 1312-1313
English
Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular control of load-dependent muscle plasticity. Thereby FAK evolves as a myocellular transducer of mechanical signals towards downstream transcript expression in myofibres. Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1042/bst0351312
- ISSN 0300-5127
- Persistent URL
- https://sonar.ch/global/documents/369
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