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Iridium-catalyzed asymmetric hydrogenation of imines.
Journal article

Iridium-catalyzed asymmetric hydrogenation of imines.

  • Baeza A Department of Chemistry, University of Basel, St. Johanns Ring 19, 4056 Basel, Switzerland.
  • Pfaltz A
  • 2010-03-12
Published in:
  • Chemistry (Weinheim an der Bergstrasse, Germany). - 2010
Catalysis
Hydrogenation
Imines
Iridium
Ligands
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Structure
Organometallic Compounds
Stereoisomerism
English We have evaluated a wide range of iridium complexes derived from chiral oxazoline-based N,P ligands for the asymmetric hydrogenation of imines and identified three efficient catalysts. These catalysts are readily synthesized by straightforward convenient routes and are air and moisture stable. In the reduction of acetophenone N-arylimines and related acyclic substrates, excellent enantioselectivities (up to 96 % ee) were obtained by using 0.1-0.5 mol % of catalyst at -20 degrees C and 5-50 bar hydrogen pressure.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/37255
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