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Amygdala ensembles encode behavioral states.

  • Gründemann J Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland. jan.grundemann@unibas.ch andreas.luthi@fmi.ch.
  • Bitterman Y Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland.
  • Lu T Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland.
  • Krabbe S Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland.
  • Grewe BF Institute of Neuroinformatics, University and ETH Zürich, Winterthurerstrasse 190, Zürich, Switzerland.
  • Schnitzer MJ Howard Hughes Medical Institute, CNC Program, James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, CA, USA.
  • Lüthi A Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland. jan.grundemann@unibas.ch andreas.luthi@fmi.ch.
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  • 2019-04-20
Published in:
  • Science (New York, N.Y.). - 2019
Affect
Animals
Anxiety
Basolateral Nuclear Complex
Calcium
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Deep Brain Stimulation
Exploratory Behavior
Fluorescence
Functional Neuroimaging
Male
Maze Learning
Mice
Mice, Inbred C57BL
Neural Pathways
Neurons
English Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are represented in amygdala circuits is unknown. By longitudinally imaging neural calcium dynamics in freely moving mice across different environments, we identified opponent changes in activity levels of two major, nonoverlapping populations of basal amygdala principal neurons. This population signature does not report global anxiety but predicts switches between exploratory and nonexploratory, defensive states. Moreover, the amygdala separately processes external stimuli and internal states and broadcasts state information via several output pathways to larger brain networks. Our findings extend the concept of thalamocortical "brain-state" coding to include affective and exploratory states and provide an entry point into the state dependency of brain function and behavior in defined circuits.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/37637
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