PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator.
Journal article

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator.

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  • 2005-04-30
Published in:
  • Science (New York, N.Y.). - 2005
English The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene.
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  • English
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closed
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https://sonar.ch/global/documents/38429
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