Mitochondrial dynamics and cancer.
- Grandemange S Department of Cell Biology, University of Geneva, Switzerland.
- Herzig S
- Martinou JC
- 2009-01-14
Published in:
- Seminars in cancer biology. - 2009
Animals
Apoptosis
Autophagy
Cell Cycle
Energy Metabolism
Humans
Mitochondria
Mitochondrial Proteins
Neoplasms
Proto-Oncogene Proteins c-bcl-2
English
Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics. In this review we report the results showing evidences of relationships between mitochondrial dynamics and cellular metabolism, autophagy or apoptosis. We discuss how different mitochondrial alterations observed in cancer cells could be linked to unbalanced mitochondrial fission or fusion events and how this could impinge on key essential cellular processes, thereby contributing to tumorigenesis.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.semcancer.2008.12.001
- PMID 19138741
- Persistent URL
- https://sonar.ch/global/documents/38536
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