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Modulation of innate and adaptive immunity by P2X ion channels.
Journal article

Modulation of innate and adaptive immunity by P2X ion channels.

  • Di Virgilio F Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Italy. Electronic address: fdv@unife.it.
  • Sarti AC Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Italy.
  • Grassi F Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Via G.B. Viotti 3/5, 20133 Milan, Italy; Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi", Via Francesco Sforza, 35-20122 Milan, Italy. Electronic address: fabio.grassi@irb.usi.ch.
  • 2018-04-10
Published in:
  • Current opinion in immunology. - 2018
Adaptive Immunity
Animals
Disease Susceptibility
Humans
Immune System
Immunity, Innate
Immunomodulation
Ion Channels
Myeloid Cells
Receptors, Purinergic P2X7
Signal Transduction
T-Lymphocytes
English Extracellular ATP is a major component of the inflammatory microenvironment where it accumulates following cell and tissue injury but also as a consequence of non-lytic release from activated inflammatory cells. In the inflammatory microenvironment ATP binds and activates nucleotide receptors of the P2Y and P2X subfamilies expressed by immune cells. P2Y receptors are G-protein-coupled, while P2X receptors are cation-selective channels. Changes in the intracellular ion homeostasis triggered by P2X receptor stimulation trigger multiple key responses crucial for initiation, propagation, and resolution of inflammation. In the P2X receptor family, the P2X7 subtype has an important role in the activation of lymphocyte, granulocyte, macrophage and dendritic cell responses. Although clinical studies have been so far rather inconclusive, it is believed that P2X7 receptor targeting might offer novel perspectives for anti-inflammatory therapy.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/39683
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