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Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial
Journal article

Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial

  • Lee, SoJung Division of Weight Management and Wellness and
  • Deldin, Anthony R. Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania;
  • White, David Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania;
  • Kim, YoonMyung University College, Yonsei University International Campus, Incheon, South Korea;
  • Libman, Ingrid Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children's Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania;
  • Rivera-Vega, Michelle Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children's Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania;
  • Kuk, Jennifer L. School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada; and
  • Sandoval, Sandra Division of Weight Management and Wellness and
  • Boesch, Chris Department of Clinical Research/AMSM, University of Bern, Bern, Switzerland
  • Arslanian, Silva Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children's Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania;
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Published in:
  • American Journal of Physiology-Endocrinology and Metabolism. - American Physiological Society. - 2013, vol. 305, no. 10, p. E1222-E1229
Physiology (medical)
Physiology
Endocrinology, Diabetes and Metabolism
English It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12–18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE ( n = 16) or RE ( n = 16) or a nonexercising control group ( n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m2·min−1) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change ( P > 0.1) in the AE (−1.31 ± 1.43 kg) and RE (−0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat (%) and IMAT decreased ( P < 0.05) in both exercise groups compared with control. Compared with control, significant ( P < 0.05) reductions in VAT (Δ−15.68 ± 7.64 cm2) and intrahepatic lipid (Δ−1.70 ± 0.74%) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg−1·min−1 per μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass ( r = −0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/40
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