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The PPARalpha-leukotriene B4 pathway to inflammation control.
Journal article

The PPARalpha-leukotriene B4 pathway to inflammation control.

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  • 1996-11-07
Published in:
  • Nature. - 1996
Adaptation, Physiological
Animals
Arachidonic Acid
Cells, Cultured
Chloramphenicol O-Acetyltransferase
Fatty Acids
Female
Gene Expression Regulation
HeLa Cells
Humans
Inflammation
Inflammation Mediators
Leukotriene B4
Ligands
Liver
Male
Mice
Oxidation-Reduction
Plasmids
Pyrimidines
Rats
Rats, Sprague-Dawley
Receptors, Cytoplasmic and Nuclear
Time Factors
Transcription Factors
Transfection
English Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent that initiates, coordinates, sustains and amplifies the inflammatory response, is shown to be an activating ligand for the transcription factor PPARalpha. Because PPARalpha regulates the oxidative degradation of fatty acids and their derivatives, like this lipid mediator, a feedback mechanism is proposed that controls the duration of an inflammatory response and the clearance of leukotriene B4 in the liver. Thus PPARalpha offers a new route to the development of anti- or pro-inflammatory reagents.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/40124
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