![Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.](/static/images/no-image.png)
Journal article
Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.
- Burkhard JA Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
- Guérot C
- Knust H
- Rogers-Evans M
- Carreira EM
- 2010-04-02
Published in:
- Organic letters. - 2010
English
Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ol1003302
- PMID 20356106
- Persistent URL
- https://sonar.ch/global/documents/40355
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