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Blood Pump Design Variations and Their Influence on Hydraulic Performance and Indicators of Hemocompatibility.
Journal article

Blood Pump Design Variations and Their Influence on Hydraulic Performance and Indicators of Hemocompatibility.

  • Wiegmann L The Interface Group, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Boës S Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
  • de Zélicourt D The Interface Group, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Thamsen B Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
  • Schmid Daners M Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
  • Meboldt M Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
  • Kurtcuoglu V The Interface Group, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. vartan.kurtcuoglu@uzh.ch.
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  • 2017-11-03
Published in:
  • Annals of biomedical engineering. - 2018
Blood damage
Centrifugal blood pump
Computational fluid dynamics
Hemolysis
Impeller design
Thrombosis
Ventricular assist device
Equipment Design
Heart-Assist Devices
Humans
Materials Testing
English Patients with ventricular assist devices still suffer from high rates of adverse events. Since many of these complications are linked to the flow field within the pump, optimization of the device geometry is essential. To investigate design aspects that influence the flow field, we developed a centrifugal blood pump using industrial guidelines. We then systematically varied selected design parameters and investigated their effects on hemodynamics and hydraulic performance using computational fluid dynamics. We analysed the flow fields based on Eulerian and Lagrangian features, shear stress histograms and six indicators of hemocompatibility. Within the investigated range of clearance gaps (50-500 µm), number of impeller blades (4-7), and semi-open versus closed shroud design, we found association of potentially damaging shear stress conditions with larger gap size and more blades. The extent of stagnation and recirculation zones was reduced with lower numbers of blades and a semi-open impeller, but it was increased with smaller clearance. The Lagrangian hemolysis index, a metric commonly applied to estimate blood damage, showed a negative correlation with hydraulic efficiency and no correlation with the Eulerian threshold-based metric.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/40802
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