Back
Larger vertebral endplate concavities cause higher failure load and work at failure under high-rate impact loading of rabbit spinal explants.
Journal article

Larger vertebral endplate concavities cause higher failure load and work at failure under high-rate impact loading of rabbit spinal explants.

  • Dudli S University Hospital Zurich, Center of Experimental Rheumatology, Lengghalde 5, 8008 Zurich, Switzerland; ETH Zurich, Institute for Biomechanics, Hönggerbergring 64, 8093 Zürich, Switzerland; University of California San Francisco, Department of Orthopaedic Surgery, 513 Parnassus Ave, 94143 San Francisco, United States. Electronic address: Stefan.Dudli@usz.ch.
  • Enns-Bray W ETH Zurich, Institute for Biomechanics, Hönggerbergring 64, 8093 Zürich, Switzerland.
  • Pauchard Y University of Calgary, McCaig Inst. for Bone and Joint Health, 2500 University Dr, Calgary, Canada.
  • Römmeler A ETH Zurich, Institute for Biomechanics, Hönggerbergring 64, 8093 Zürich, Switzerland.
  • Fields AJ University of California San Francisco, Department of Orthopaedic Surgery, 513 Parnassus Ave, 94143 San Francisco, United States.
  • Ferguson SJ ETH Zurich, Institute for Biomechanics, Hönggerbergring 64, 8093 Zürich, Switzerland.
  • Helgason B ETH Zurich, Institute for Biomechanics, Hönggerbergring 64, 8093 Zürich, Switzerland; School of Science and Engineering, Reykjavik University, Menntavegur 1, Reykjavík, Iceland.
Show more…
  • 2018-02-08
Published in:
  • Journal of the mechanical behavior of biomedical materials. - 2018
Endplate
Fracture
High-rate
Intervertebral disc
Morphometry
Vertebra
Animals
Rabbits
Risk Assessment
Spinal Fractures
Stress, Mechanical
Weight-Bearing
English Vertebral fractures are among the most common of all osteoporosis related fracture types and its risk assessment is largely based on bone quality measures. Morphometric parameters are not yet considered, although endplate thickness and concavity shape were found to be important in fracture prediction in low-rate tests. We hypothesized that, under high-rate impact loading, the shape and size of the central endplate concavity are of key importance for fracture prediction. Therefore, we tested rabbit spinal segment explants in vitro under high-rate impact loading. With a combination of microCT to describe endplate morphometry, high-speed video imaging, and impact force measurement, endplate morphometry was correlated to the mechanical response. We found that endplate concavity shape and volume were important in describing the mechanical response: larger concavities caused higher failure load. We suggest a model for the fracture mechanism under high-rate impact loading, considering the morphometry of the endplates: wider and more voluminous concavities are protective whereas steeper slopes of the concavity edges and increasing bone volume fraction of the central endplate moiety are disadvantageous. Therefore, the shape and size of endplate morphometry are important in vertebral fracture prediction and should be considered included in vertebral fracture risk assessment.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/40868
Statistics
Document views: 31 File downloads: