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Nuclear import in viral infections.
Journal article

Nuclear import in viral infections.

  • Greber UF Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. ufgreber@zool.unizh.ch
  • Fornerod M
  • 2004-12-22
Published in:
  • Current topics in microbiology and immunology. - 2005
Animals
DNA Virus Infections
DNA Viruses
Humans
Nuclear Pore
Nuclear Proteins
RNA Virus Infections
RNA Viruses
Receptors, Virus
Viral Proteins
Virus Physiological Phenomena
English The separation of transcription in the nucleus and translation in the cytoplasm requires nucleo-cytoplasmic exchange of proteins and RNAs. Viruses have evolved strategies to capitalize on the nucleo-cytoplasmic trafficking machinery of the cell. Here, we first discuss the principal mechanisms of receptor-mediated nuclear import of proteinaceous cargo through the nuclear pore complex, the gate keeper of the cell nucleus. We then focus on viral strategies leading to nuclear import of genomes and subgenomic particles. Nucleo-cytoplasmic transport is directly important for those viruses that are replicating in the nucleus, such as DNA tumor viruses and RNA viruses, including parvoviruses, the DNA retroviruses hepadnaviruses, RNA-retrotransposons and retroviruses, adenoviruses, herpesviruses, papovaviruses, and particular negative-sense RNA viruses, such as the orthomyxovirus influenza virus. The viral strategies of nuclear import turn out to be surprisingly diverse. Their investigation continues to give insight into how nucleic acids pass in and out of the nucleus.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/4092
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