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Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa.
Journal article

Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa.

  • Brel O Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
  • Touré S Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
  • Levasseur M Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
  • Lechat C ASCOFrance, 79360, Villiers-en-bois, France.
  • Pellissier L School of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva 4, Switzerland.
  • Wolfender JL School of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva 4, Switzerland.
  • Van-Elslande E Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
  • Litaudon M Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
  • Dusfour I Institut Pasteur de la Guyane, Unité de Contrôle et Adaptation des Vecteurs, BP6010, 97306 Cayenne, France.
  • Stien D Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, Sorbonne Universités, UPMC Univ. Paris 06, CNRS, 66650 Banyuls-sur-Mer, France.
  • Eparvier V Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
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  • 2020-10-06
Published in:
  • Journal of natural products. - 2020
Organic Chemistry
Complementary and alternative medicine
Analytical Chemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmaceutical Science
English Fifty-seven entomopathogenic microorganisms were screened against human pathogens and subjected to mass spectrometry molecular networking based dereplication. Isaria farinosa BSNB-1250, shown to produce potentially novel biologically active metabolites, was grown on a large scale on potato dextrose agar, and paecilosetin (1) and five new analogues (2-6) were subsequently isolated. The structures of the new compounds were elucidated using 1D and 2D NMR. The absolute configurations of compounds 1-6 were determined using Mosher ester derivatives (1, 3, 4), comparison of experimental and calculated ECD spectra (2-4 and 6), and single-crystal X-ray diffraction analysis (5). Compounds 1 and 5 exhibited strong antibacterial activity against MSSA and MRSA with MIC values of 1-2 μg/mL.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/42701
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