Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa.

Brel O; Touré S; Levasseur M; Lechat C; Pellissier L; Wolfender JL; Van-Elslande E; Litaudon M; Dusfour I; Stien D; Eparvier V

doi:10.1021/acs.jnatprod.0c00444

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Journal article

Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa.

Brel O Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
Touré S Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
Levasseur M Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
Lechat C ASCOFrance, 79360, Villiers-en-bois, France.
Pellissier L School of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva 4, Switzerland.
Wolfender JL School of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva 4, Switzerland.
Van-Elslande E Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
Litaudon M Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.
Dusfour I Institut Pasteur de la Guyane, Unité de Contrôle et Adaptation des Vecteurs, BP6010, 97306 Cayenne, France.
Stien D Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, Sorbonne Universités, UPMC Univ. Paris 06, CNRS, 66650 Banyuls-sur-Mer, France.
Eparvier V Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France.

2020-10-06

Published in:

Journal of natural products. - 2020

Complementary and alternative medicine

English Fifty-seven entomopathogenic microorganisms were screened against human pathogens and subjected to mass spectrometry molecular networking based dereplication. Isaria farinosa BSNB-1250, shown to produce potentially novel biologically active metabolites, was grown on a large scale on potato dextrose agar, and paecilosetin (1) and five new analogues (2-6) were subsequently isolated. The structures of the new compounds were elucidated using 1D and 2D NMR. The absolute configurations of compounds 1-6 were determined using Mosher ester derivatives (1, 3, 4), comparison of experimental and calculated ECD spectra (2-4 and 6), and single-crystal X-ray diffraction analysis (5). Compounds 1 and 5 exhibited strong antibacterial activity against MSSA and MRSA with MIC values of 1-2 μg/mL.

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