Journal article

Pulmonary Disease due toMycobacterium tuberculosisin a Horse: Zoonotic Concerns and Limitations of Antemortem Testing

  • Lyashchenko, Konstantin P. Research and Development Department, Chembio Diagnostic Systems, Inc., 3661 Horseblock Road, Medford, NY 11763, USA
  • Greenwald, Rena Research and Development Department, Chembio Diagnostic Systems, Inc., 3661 Horseblock Road, Medford, NY 11763, USA
  • Esfandiari, Javan Research and Development Department, Chembio Diagnostic Systems, Inc., 3661 Horseblock Road, Medford, NY 11763, USA
  • Lecu, Alexis Museum National d'Histoire Naturelle Department, Paris Zoo, 53 Avenue de Saint-Maurice, 75012 Paris, France
  • Waters, W. Ray Infectious Bacterial Diseases Research Unit, National Animal Disease Center, Ames, IA 50010, USA
  • Posthaus, Horst Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, Switzerland
  • Bodmer, Thomas Institute for Infectious Diseases, Medical Faculty, University of Bern, 3010 Bern, Switzerland
  • Janssens, Jean-Paul Division of Pulmonary Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland
  • Aloisio, Fabio Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, Switzerland
  • Graubner, Claudia Equine Clinic, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, Switzerland
  • Grosclaude, Eléonore Cantonal Veterinary Office Geneva, Quai Ernest-Ansermet 22, Plainpalais P.O. Box 76, 1211 Geneva 4, Switzerland
  • Piersigilli, Alessandra Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, P.O. Box 8466, 3001 Bern, Switzerland
  • Schiller, Irene Monitoring Department, Swiss Federal Veterinary Office, Schwarzenburgstrasse 155, 3003 Bern, Switzerland
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Published in:
  • Veterinary Medicine International. - Hindawi Limited. - 2012, vol. 2012, p. 1-6
English A case of pulmonary tuberculosis caused byMycobacterium tuberculosiswas diagnosed in a horse. Clinical evaluation performed prior to euthanasia did not suggest tuberculosis, but postmortem examination provided pathological and bacteriological evidence of mycobacteriosis. In the lungs, multiple tuberculoid granulomas communicating with the bronchiolar lumen, pleural effusion, and a granulomatous lymphadenitis involving mediastinal and tracheobronchial lymph nodes were found. Serologic response toM. tuberculosisantigens was detected in the infected horse, but not in the group of 42 potentially exposed animals (18 horses, 14 alpacas, 6 donkeys, and 4 dogs) which showed no signs of disease. Diagnosis of tuberculosis in live horses remains extremely difficult. Four of 20 animal handlers at the farm were positive for tuberculous infection upon follow-up testing by interferon-gamma release assay, indicating a possibility of interspecies transmission ofM. tuberculosis.
Language
  • English
Open access status
gold
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https://sonar.ch/global/documents/428
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