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Journal article

CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.

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  • 2000-12-06
Published in:
  • The Journal of experimental medicine. - 2000
Animals
B-Lymphocytes
Chemokine CCL19
Chemokine CCL21
Chemokine CXCL12
Chemokine CXCL13
Chemokines, CC
Chemokines, CXC
Chemotaxis, Leukocyte
Cytokines
Germinal Center
Humans
Immunoglobulin Isotypes
Leukocyte Common Antigens
Leukocytes, Mononuclear
Lymphoid Tissue
Palatine Tonsil
Receptors, CCR7
Receptors, CXCR5
Receptors, Chemokine
Receptors, Cytokine
Receptors, Lymphocyte Homing
T-Lymphocytes, Helper-Inducer
English Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We have studied the functional properties of a human T cell subset marked by the expression of CXC chemokine receptor 5 (CXCR5). Memory but not naive T cells from tonsils are CXCR5(+) and migrate in response to the B cell-attracting chemokine 1 (BCA-1), which is selectively expressed by reticular cells and blood vessels within B cell follicles. Tonsillar CXCR5(+) T cells do not respond to other chemokines present in secondary lymphoid tissues, including secondary lymphoid tissue chemokine (SLC), EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell-derived factor 1 (SDF-1). The involvement of tonsillar CXCR5(+) T cells in humoral immune responses is suggested by their localization in the mantle and light zone germinal centers of B cell follicles and by the concomitant expression of activation and costimulatory markers, including CD69, HLA-DR, and inducible costimulator (ICOS). Peripheral blood CXCR5(+) T cells also belong to the CD4(+) memory T cell subset but, in contrast to tonsillar cells, are in a resting state and migrate weakly to chemokines. CXCR5(+) T cells are very inefficient in the production of cytokines but potently induce antibody production during coculture with B cells. These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH)).
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/430
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