Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae.
- Meyer Sauteur PM Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
- de Bruijn ACJM Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
- Graça C Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
- Tio-Gillen AP Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
- Estevão SC Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
- Hoogenboezem T Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
- Hendriks RW Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
- Berger C Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Zurich, Switzerland.
- Jacobs BC Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
- van Rossum AMC Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
- Huizinga R Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
- Unger WWJ Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands w.unger@erasmusmc.nl.
- 2018-11-07
Published in:
- Infection and immunity. - 2019
Bruton tyrosine kinase
Guillain-Barré syndrome
Mycoplasma pneumoniae
antibodies
autoimmunity
encephalitis
galactocerebroside
molecular mimicry
pneumonia
vaccine
Animals
Antibodies, Bacterial
Bacterial Proteins
Child
Glycolipids
Humans
Immunoglobulin G
Immunoglobulin M
Mice
Mycoplasma pneumoniae
Pneumonia, Mycoplasma
English
Antibody responses to Mycoplasma pneumoniae correlate with pulmonary M. pneumoniae clearance. However, M. pneumoniae-specific IgG antibodies can cross-react with the myelin glycolipid galactocerebroside (GalC) and cause neurological disorders. We assessed whether antiglycolipid antibody formation is part of the physiological immune response to M. pneumoniae We show that antibodies against M. pneumoniae proteins and glycolipids arise in serum of M. pneumoniae-infected children and mice. Although antibodies to M. pneumoniae glycolipids were mainly IgG, anti-GalC antibodies were only IgM. B-1a cells, shown to aid in protection against pathogen-derived glycolipids, are lacking in Bruton tyrosine kinase (Btk)-deficient mice. M. pneumoniae-infected Btk-deficient mice developed M. pneumoniae-specific IgG responses to M. pneumoniae proteins but not to M. pneumoniae glycolipids, including GalC. The equal recovery from M. pneumoniae infection in Btk-deficient and wild-type mice suggests that pulmonary M. pneumoniae clearance is predominantly mediated by IgG reactive with M. pneumoniae proteins and that M. pneumoniae glycolipid-specific IgG or IgM is not essential. These data will guide the development of M. pneumoniae-targeting vaccines that avoid the induction of neurotoxic antibodies.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1128/IAI.00663-18
- PMID 30396892
- Persistent URL
- https://sonar.ch/global/documents/4333
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