Astrocytes: Orchestrating synaptic plasticity?
- De Pittà M Department of Neurobiology, The University of Chicago, Chicago, IL, USA; EPI BEAGLE, INRIA Rhône-Alpes, Villeurbanne, France. Electronic address: mauriziodepitta@gmail.com.
- Brunel N Department of Neurobiology, The University of Chicago, Chicago, IL, USA; Department of Statistics, The University of Chicago, Chicago, IL, USA.
- Volterra A Département de Neurosciences Fondamentales, Université de Lausanne, Switzerland. Electronic address: Andrea.Volterra@unil.ch.
- 2015-04-12
Published in:
- Neuroscience. - 2016
astrocyte
gliotransmission
synaptic plasticity
Animals
Astrocytes
Humans
Neuronal Plasticity
Neurons
Synapses
Synaptic Transmission
English
Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that remains debated is how the plasticity mechanisms, that encompass a broad spectrum of temporal and spatial scales, come to play together in a concerted fashion. Here we review and discuss evidence that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.neuroscience.2015.04.001
- PMID 25862587
- Persistent URL
- https://sonar.ch/global/documents/43359
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