Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
- Gonzalez-Jaramillo, Valentina ORCID Institute of Social and Preventive Medicine (ISPM), University of Bern, 3012, Bern, Switzerland
- Portilla-Fernandez, Eliana ORCID Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015 CN, Rotterdam, Netherlands
- Glisic, Marija Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany
- Voortman, Trudy Department of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, Netherlands
- Ghanbari, Mohsen Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, 13131, Mashhad, Iran
- Bramer, Wichor Medical Library, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, Netherlands
- Chowdhury, Rajiv Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, CB1 8RN, Cambridge, UK
- Nijsten, Tamar Department of Dermatology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, Netherlands
- Dehghan, Abbas Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG, London, UK
- Franco, Oscar H. Institute of Social and Preventive Medicine (ISPM), University of Bern, 3012, Bern, Switzerland
- Nano, Jana German Center for Diabetes Research (DZD), D-85764, Munich-Neuherberg, Germany
Published in:
- International Journal of Inflammation. - Hindawi Limited. - 2019, vol. 2019, p. 1-14
English
Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. Five bibliographic databases were screened until 21 November of 2017. We included studies conducted on humans that examined the association between epigenetic marks (DNA methylation and/or histone modifications) and a comprehensive list of inflammatory markers. Of the 3,759 identified references, 24 articles were included, involving, 17,399 individuals. There was suggestive evidence for global hypomethylation but better-quality studies in the future have to confirm this. Epigenome-wide association studies (EWAS) (n=7) reported most of the identified differentially methylated genes to be hypomethylated in inflammatory processes. Candidate genes studies reported 18 differentially methylated genes related to several circulatory inflammation markers. There was no overlap in the methylated sites investigated in candidate gene studies and EWAS, except for TMEM49, which was found to be hypomethylated with higher inflammatory markers in both types of studies. The relation between histone modifications and inflammatory markers was assessed by one study only. This review supports an association between epigenetic marks and inflammation, suggesting hypomethylation of the genome. Important gaps in the quality of studies were reported such as inadequate sample size, lack of adjustment for relevant confounders, and failure to replicate the findings. While most of the studies have been focused on C-reactive protein, further efforts should investigate other inflammatory markers.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1155/2019/6273680
- ISSN 2090-8040
- Persistent URL
- https://sonar.ch/global/documents/434
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