Journal article
Implication of reward alterations in the expression of negative symptoms in 22q11.2 deletion syndrome: a behavioural and DTI study.
- Dubourg L Department of Psychiatry,Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva,Geneva,Switzerland.
- Schneider M Department of Psychiatry,Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva,Geneva,Switzerland.
- Padula MC Department of Psychiatry,Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva,Geneva,Switzerland.
- Chambaz L Department of Psychiatry,Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva,Geneva,Switzerland.
- Schaer M Department of Psychiatry,Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva,Geneva,Switzerland.
- Eliez S Department of Psychiatry,Office Médico-Pédagogique Research Unit, School of Medicine, University of Geneva,Geneva,Switzerland.
- 2017-01-24
Published in:
- Psychological medicine. - 2017
22q11.2 deletion syndrome
negative symptoms
reward system
white matter
Adolescent
Adult
Child
DiGeorge Syndrome
Diffusion Tensor Imaging
Female
Humans
Male
Pleasure
Reward
White Matter
Young Adult
English
BACKGROUND
Alterations of the reward system have been proposed as one of the core mechanisms underlying the expression of negative symptoms in schizophrenia. Specifically, deficits in specific reward components and white matter (WM) integrity of the reward system have been highlighted. The putative link between negative symptoms and the hedonic experience, or structural connectivity of the reward system has never been examined in the 22q11.2 deletion syndrome (22q11DS), a condition with increased risk for psychosis.
METHOD
Anticipatory and consummatory dimensions of pleasure were assessed in participants with 22q11DS (N = 54) and healthy controls (N = 55). In patients with 22q11DS, the association between pleasure scores and positive or negative symptoms was investigated. Furthermore, WM integrity of the accumbofrontal tract was quantified using diffusion tensor imaging (DTI). Associations between DTI measures, pleasure dimensions and negative symptoms were examined.
RESULTS
Patients with 22q11DS showed reduced anticipatory and consummatory pleasure compared to controls. Furthermore, anticipatory pleasure scores were negatively correlated to negative and positive symptoms in 22q11DS. WM microstructural changes of the accumbofrontal tract in terms of increased fractional anisotropy and reduced radial anisotropy were also identified in patients. However, no significant correlation between the DTI measures and pleasure dimensions or psychotic symptoms was observed.
CONCLUSIONS
This study revealed that participants with 22q11DS differed in their experience of pleasure compared to controls. The anticipatory pleasure component appears to be related to negative and positive symptom severity in patients. Alterations of WM integrity of the accumbofrontal tract seem to be related to myelination abnormalities in 22q11DS patients.
Alterations of the reward system have been proposed as one of the core mechanisms underlying the expression of negative symptoms in schizophrenia. Specifically, deficits in specific reward components and white matter (WM) integrity of the reward system have been highlighted. The putative link between negative symptoms and the hedonic experience, or structural connectivity of the reward system has never been examined in the 22q11.2 deletion syndrome (22q11DS), a condition with increased risk for psychosis.
METHOD
Anticipatory and consummatory dimensions of pleasure were assessed in participants with 22q11DS (N = 54) and healthy controls (N = 55). In patients with 22q11DS, the association between pleasure scores and positive or negative symptoms was investigated. Furthermore, WM integrity of the accumbofrontal tract was quantified using diffusion tensor imaging (DTI). Associations between DTI measures, pleasure dimensions and negative symptoms were examined.
RESULTS
Patients with 22q11DS showed reduced anticipatory and consummatory pleasure compared to controls. Furthermore, anticipatory pleasure scores were negatively correlated to negative and positive symptoms in 22q11DS. WM microstructural changes of the accumbofrontal tract in terms of increased fractional anisotropy and reduced radial anisotropy were also identified in patients. However, no significant correlation between the DTI measures and pleasure dimensions or psychotic symptoms was observed.
CONCLUSIONS
This study revealed that participants with 22q11DS differed in their experience of pleasure compared to controls. The anticipatory pleasure component appears to be related to negative and positive symptom severity in patients. Alterations of WM integrity of the accumbofrontal tract seem to be related to myelination abnormalities in 22q11DS patients.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1017/S0033291716003482
- PMID 28112057
- Persistent URL
- https://sonar.ch/global/documents/43466
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