Journal article
Hand perceptions induced by single pulse transcranial magnetic stimulation over the primary motor cortex.
- Franza M Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Laboratory of Cognitive Neuroscience, Brain Mind Institute, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus SUVA, Sion, Switzerland.
- Sorrentino G Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Laboratory of Cognitive Neuroscience, Brain Mind Institute, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus SUVA, Sion, Switzerland.
- Vissani M MySpace Lab, Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland.
- Serino A MySpace Lab, Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland.
- Blanke O Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Laboratory of Cognitive Neuroscience, Brain Mind Institute, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus SUVA, Sion, Switzerland; Department of Neurology, University Hospital Geneva, Switzerland.
- Bassolino M Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Laboratory of Cognitive Neuroscience, Brain Mind Institute, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus Biotech, Geneva, Switzerland; Center for Neuroprosthetics, School of Life Science, Swiss Federal Institute of Technology (Ecole Polytechnique Fédérale de Lausanne), Campus SUVA, Sion, Switzerland. Electronic address: michela.bassolino@epfl.ch.
- 2019-01-07
Published in:
- Brain stimulation. - 2019
Absolute threshold
Motor evoked potentials
Primary motor cortex
TMS-evoked hand perceptions
TMS-evoked movements
Transcranial magnetic stimulation (TMS)
Adult
Evoked Potentials, Motor
Female
Hand
Humans
Male
Motor Cortex
Movement
Muscle Contraction
Perception
Transcranial Magnetic Stimulation
English
BACKGROUND
When single pulse transcranial magnetic stimulation (TMS) is applied over the primary motor cortex (M1) with sufficient intensity, it evokes muscular contractions (motor-evoked potentials, MEPs) and muscle twitches (TMS-evoked movements). Participants may also report various hand sensations related to TMS, but the perception elicited by TMS and its relationship to MEPs and evoked movements has not been systematically studied.
OBJECTIVE
The main aim of this work is to evaluate participants' kinesthetic and somatosensory hand perceptions elicited by single-pulse TMS over M1-hand area at different intensities of stimulation and their relation with MEPs and TMS-evoked movements.
METHODS
We compared the number of MEPs (measured by electromyography), TMS-evoked movements (measured by an accelerometer) and participants' hand perception (measured by verbal report) elicited by TMS at different intensity of stimulation. This way, we estimated the amplitude of MEPs and the acceleration of TMS-evoked movements sufficient to trigger TMS evoked hand perceptions.
RESULTS
We found that TMS-evoked hand perceptions are induced at 105% of the individual resting motor threshold, a value significantly different from the threshold inducing MEPs (about 100%) and TMS-evoked movements (about 110%). Our data indicate that only MEPs with an amplitude higher than 0.62 mV and TMS-evoked movements with acceleration higher than 0.42 m/s2 were associated with hand perceptions at threshold.
CONCLUSIONS
Our data reveal the main features of TMS-evoked hand perception and show that in addition to MEPs and TMS-evoked movements, this is a separate discernible response associated to single-pulse TMS over M1.
When single pulse transcranial magnetic stimulation (TMS) is applied over the primary motor cortex (M1) with sufficient intensity, it evokes muscular contractions (motor-evoked potentials, MEPs) and muscle twitches (TMS-evoked movements). Participants may also report various hand sensations related to TMS, but the perception elicited by TMS and its relationship to MEPs and evoked movements has not been systematically studied.
OBJECTIVE
The main aim of this work is to evaluate participants' kinesthetic and somatosensory hand perceptions elicited by single-pulse TMS over M1-hand area at different intensities of stimulation and their relation with MEPs and TMS-evoked movements.
METHODS
We compared the number of MEPs (measured by electromyography), TMS-evoked movements (measured by an accelerometer) and participants' hand perception (measured by verbal report) elicited by TMS at different intensity of stimulation. This way, we estimated the amplitude of MEPs and the acceleration of TMS-evoked movements sufficient to trigger TMS evoked hand perceptions.
RESULTS
We found that TMS-evoked hand perceptions are induced at 105% of the individual resting motor threshold, a value significantly different from the threshold inducing MEPs (about 100%) and TMS-evoked movements (about 110%). Our data indicate that only MEPs with an amplitude higher than 0.62 mV and TMS-evoked movements with acceleration higher than 0.42 m/s2 were associated with hand perceptions at threshold.
CONCLUSIONS
Our data reveal the main features of TMS-evoked hand perception and show that in addition to MEPs and TMS-evoked movements, this is a separate discernible response associated to single-pulse TMS over M1.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.brs.2018.12.972
- PMID 30611706
- Persistent URL
- https://sonar.ch/global/documents/43749
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