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Repair and translesion DNA polymerases as anticancer drug targets.
Journal article

Repair and translesion DNA polymerases as anticancer drug targets.

  • Maga G Ulrich Hübscher Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, Zürich, Switzerland.
  • Hübscher U
  • 2008-05-14
Published in:
  • Anti-cancer agents in medicinal chemistry. - 2008
Animals
Antineoplastic Agents
DNA Damage
DNA Repair
Enzyme Inhibitors
Humans
Molecular Structure
Neoplasms
Nucleic Acid Synthesis Inhibitors
English We have very recently highlighted possible connections between DNA polymerases, the main enzymes in the DNA metabolism, and human diseases (Ramadan, K., Maga, G. and Hübscher, U.: DNA polymerases and diseases, In: Genome Integrity: Facets and Perspectives ed. Lankenau, D.-H. Springer Verlag, Heidelberg Germany, Vol 1, pp. 69-102, 2007). Beside a role in DNA replication of the genome DNA polymerases have fundamental functions in other aspect of DNA metabolism, such as DNA repair, DNA recombination, translesion DNA synthesis and cell cycle checkpoint. In the last decade many novel DNA polymerases have been identified, but their exact cellular functions still await clarification. We know that many DNA polymerases have redundant functions. It is a fact that specific inhibition of certain DNA polymerases is a promising approach to develop anticancer drugs. In this review we will concentrate on DNA repair proteins and translesion DNA polymerases as possible targets for anti cancer drugs.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/4402
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