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Survival and Outcome After Poor-Grade Aneurysmal Subarachnoid Hemorrhage in Elderly Patients.
Journal article

Survival and Outcome After Poor-Grade Aneurysmal Subarachnoid Hemorrhage in Elderly Patients.

  • Goldberg J From the Department of Neurosurgery (J. Goldberg, D.S., W.Z., A.R., J.B., C.F.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Schoeni D From the Department of Neurosurgery (J. Goldberg, D.S., W.Z., A.R., J.B., C.F.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Mordasini P Department of Diagnostic and Interventional Neuroradiology (P.M., J. Gralla), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Z'Graggen W From the Department of Neurosurgery (J. Goldberg, D.S., W.Z., A.R., J.B., C.F.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Gralla J Department of Diagnostic and Interventional Neuroradiology (P.M., J. Gralla), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Raabe A From the Department of Neurosurgery (J. Goldberg, D.S., W.Z., A.R., J.B., C.F.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Beck J From the Department of Neurosurgery (J. Goldberg, D.S., W.Z., A.R., J.B., C.F.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
  • Fung C From the Department of Neurosurgery (J. Goldberg, D.S., W.Z., A.R., J.B., C.F.), Inselspital, Bern University Hospital, University of Bern, Switzerland.
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  • 2018-12-21
Published in:
  • Stroke. - 2018
aneurysm
elderly
odds ratio
outcome
subarachnoid hemorrhage
survival analysis
Age Factors
Aged
Aged, 80 and over
Aneurysm, Ruptured
Female
Humans
Intracranial Aneurysm
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prognosis
Proportional Hazards Models
Retrospective Studies
Rupture, Spontaneous
Subarachnoid Hemorrhage
Survival Analysis
Survival Rate
Switzerland
English Background and Purpose- Whether maximal treatment should be offered to elderly patients suffering from poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is controversial. The survival of patients in this subgroup beyond the usual outcome measurements 6 to 12 months after aSAH is unclear. The purpose of this study is to provide survival and outcome data to support clinicians making decisions on treatment for this subgroup of patients. Methods- We performed a retrospective analysis of the Bernese SAH database for poor-grade (World Federation of Neurosurgical Societies grade IV and V) elderly patients (age ≥60 years) suffering from aSAH admitted to our institution from 2005 to 2017. Patients were divided into 3 age groups (60-69, 70-79, and 80-90 years). Survival analysis was performed to estimate mean survival and hazard ratios for death. Binary logarithmic regression was used to estimate the odds ratio for favorable (modified Rankin Scale score of 0-3) and unfavorable (modified Rankin Scale score of 4-6) outcome. Results- Increasing age was associated with an increasing risk of death after aSAH. The hazard ratio increased by 6% per year of age ( P<0.001; hazard ratio, 1.06; 95% CI, 1.03-1.09) and 76% per decade ( P<0.001; hazard ratio, 1.76; 95% CI, 1.35-2.29). Mean survival was 56.3±8 months (patients aged 60-69 years), 31.6±7.6 months (70-79 years), and 7.6±5.8 months (80-90 years). Unfavorable outcomes 6 to 12 months after aSAH were strongly related to older age. The odds ratio increased by 11% per year of age ( P<0.001; odds ratio, 1.11; 95% CI, 1.05-1.18) and 192% per decade ( P<0.001; odds ratio, 2.92; 95% CI, 1.63-5.26). Conclusions- Risk for death and unfavorable outcome increases markedly with older age in elderly patients with poor-grade aSAH. Despite a high initial mortality, treatment resulted in a reasonable proportion of favorable outcomes up to 79 years of age and only a small number of patients who were moderately or severely disabled 6 to 12 months after aSAH. Mean survival and proportion of favorable outcomes decreased markedly in patients older than 80 years.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/44077
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