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Journal article

Linking dosage compensation and X chromosome nuclear organization in C. elegans.

  • Sharma R a Cell Fate and Nuclear Organization ; Institute of Cell Biology ; University of Bern ; Bern , Switzerland.
  • Meister P
  • 2015-06-10
Published in:
  • Nucleus (Austin, Tex.). - 2015
C. elegans
X chromosome
chromatin compaction
dosage compensation
nuclear organization
nuclear pores
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Disorders of Sex Development
Dosage Compensation, Genetic
Epigenetic Repression
Female
Male
X Chromosome
English Animal sex is determined by the number of X chromosomes in many species, creating unequal gene dosage (aneuploidy) between sexes. Dosage Compensation mechanisms equalize this dosage difference by regulating X-linked gene expression. In the nematode C. elegans the current model suggests that DC is achieved by a 2-fold transcriptional downregulation in hermaphrodites mediated by the Dosage Compensation Complex (DCC), which restricts access to RNA Polymerase II by an unknown mechanism. Taking a nuclear organization point of view, we showed that the male X chromosome resides in the pore proximal subnuclear compartment whereas the DCC bound to the X, inhibits this spatial organization in the hermaphrodites. Here we discuss our results and propose a model that reassigns the role of DCC from repression of genes to inhibition of activation.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/44099
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