A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.
- Strauss C Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
- Hu Y Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.
- Coates A Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.
- Perreten V Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland vincent.perreten@vetsuisse.unibe.ch.
- 2016-11-02
Published in:
- Antimicrobial agents and chemotherapy. - 2017
23S RNA methylase
MLSB
Staphylococcus
antibiotic resistance
coagulase-negative staphylococci
macrolides-lincosamides-streptogramin B
phages
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Genomic Islands
Humans
Lincosamides
Macrolides
Microbial Sensitivity Tests
Staphylococcus
Staphylococcus aureus
Streptogramin B
Streptogramins
English
A novel erm(44) gene variant, erm(44)v, has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44)v gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1128/AAC.01655-16
- PMID 27799208
- Persistent URL
- https://sonar.ch/global/documents/44108
Statistics
Document views: 24
File downloads:
- fulltext.pdf: 0