Journal article
Metabolic and epigenetic regulation of T-cell exhaustion.
- Franco F Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
- Jaccard A Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
- Romero P Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
- Yu YR Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland. yi-ru.yu@unil.ch.
- Ho PC Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland. ping-chih.ho@unil.ch.
- 2020-09-22
Published in:
- Nature metabolism. - 2020
English
Current immunotherapies yield remarkable clinical outcomes by boosting the power of host immunity in cancer cell elimination and viral clearance. However, after prolonged antigen exposure, CD8+ T cells differentiate into a special differentiation state known as T-cell exhaustion, which poses one of the major hurdles to antiviral and antitumor immunity during chronic viral infection and tumour development. Growing evidence indicates that exhausted T cells undergo metabolic insufficiency with altered signalling cascades and epigenetic landscapes, which dampen effector immunity and cause poor responsiveness to immune-checkpoint-blockade therapies. How metabolic stress affects T-cell exhaustion remains unclear; therefore, in this Review, we summarize current knowledge of how T-cell exhaustion occurs, and discuss how metabolic insufficiency and prolonged stress responses may affect signalling cascades and epigenetic reprogramming, thus locking T cells into an exhausted state via specialized differentiation programming.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1038/s42255-020-00280-9
- PMID 32958939
- Persistent URL
- https://sonar.ch/global/documents/44656
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