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Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.

  • Jones SE Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • van Hees VT Netherlands eScience Center, Amsterdam, 1098 XG, The Netherlands.
  • Mazzotti DR Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, 19104, PA, USA.
  • Marques-Vidal P Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
  • Sabia S Research Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
  • van der Spek A Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
  • Dashti HS Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Engmann J UCL Institute of Cardiovascular Science, Research department of Population Science and Experimental Medicine, Centre for Translational Genomics, 222 Euston Road, London, NW1 2DA, UK.
  • Kocevska D Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
  • Tyrrell J Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Beaumont RN Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Hillsdon M Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX1 2LU, UK.
  • Ruth KS Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Tuke MA Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Yaghootkar H Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Sharp SA Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Ji Y Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Harrison JW Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Freathy RM Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Murray A Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Luik AI Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
  • Amin N Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
  • Lane JM Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Saxena R Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Rutter MK Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PL, UK.
  • Tiemeier H Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
  • Kutalik Z Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, 1010, Switzerland.
  • Kumari M ISER, University of Essex, Colchester, Essex, CO4 3SQ, UK.
  • Frayling TM Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
  • Weedon MN Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK. m.n.weedon@exeter.ac.uk.
  • Gehrman PR Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, 19104, PA, USA.
  • Wood AR Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK. a.r.wood@exeter.ac.uk.
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  • 2019-04-07
Published in:
  • Nature communications. - 2019
Accelerometry
Circadian Rhythm
Humans
Polymorphism, Single Nucleotide
Polysomnography
Serotonin
Sleep
Sleep Wake Disorders
Waist-Hip Ratio
English Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10-8, of which 20 reach a stricter threshold of P < 8 × 10-10. These include 26 novel associations with measures of sleep quality and 10 with nocturnal sleep duration. The majority of identified variants associate with a single sleep trait, except for variants previously associated with restless legs syndrome. For sleep duration we identify a missense variant (p.Tyr727Cys) in PDE11A as the likely causal variant. As a group, sleep quality loci are enriched for serotonin processing genes. Although accelerometer-derived measures of sleep are imperfect and may be affected by restless legs syndrome, these findings provide new biological insights into sleep compared to previous efforts based on self-report sleep measures.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/44745
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