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Interleukin 15 stimulates production of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by human peripheral blood mononuclear cells.
Journal article

Interleukin 15 stimulates production of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by human peripheral blood mononuclear cells.

  • 2001-03-10
Published in:
  • Cytokine. - 2001
Cells, Cultured
Enzyme Activation
Enzyme Precursors
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-15
Leukocytes, Mononuclear
Lymphocyte Activation
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
T-Lymphocytes
Tissue Inhibitor of Metalloproteinase-1
English In peripheral blood mononuclear cells (PBMC), matrix metalloproteinase (MMP)-9 mediates the extravasation of immune cells and may be involved in tissue destruction during inflammation. We investigated the effect of the pro-inflammatory cytokines interleukin (IL-)12 and 15 on the secretion of MMP-9 in PBMC. IL-15, but not IL-12, induces MMP-9 in PBMC and in T cells. Moreover, the combination of IL-15 and IL-2 had an additive effect. In contrast, both IL-12 and IL-15 induced the release of tissue inhibitor of metalloproteinases (TIMP)-1. IL-15 led to a dose-dependent increase of the MMP-9/TIMP-1 ratio as a measure for increased proteolytic capacity. We conclude that IL-15 mediates its effects in inflammation in part through MMP-9.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/4535
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