TOR signaling in growth and metabolism.
- Wullschleger S Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
- Loewith R
- Hall MN
- 2006-02-14
Published in:
- Cell. - 2006
Aging
Animals
Cell Proliferation
Humans
Memory
Models, Biological
Protein Kinases
Protein-Serine-Threonine Kinases
Saccharomyces cerevisiae Proteins
Signal Transduction
TOR Serine-Threonine Kinases
English
The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to environmental cues. Here, highlighting contributions from studies in model organisms, we review mammalian TOR complexes and the signaling branches they mediate. TOR is part of two distinct multiprotein complexes, TOR complex 1 (TORC1), which is sensitive to rapamycin, and TORC2, which is not. The physiological consequences of mammalian TORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.cell.2006.01.016
- PMID 16469695
- Persistent URL
- https://sonar.ch/global/documents/45631
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